2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
1: concentrated H2SO4; concentrated HNO3 2: acetic acid; bromine View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
iron sulphate heptahydrate; sulfuric acid; boric acid in water; glycerol T=0 - 135°C; 4 h;
参考文献
Liu, Xingjiang; Chen, Mingxing; Liu, Ziping; Yu, Mingming; Wei, Liuhe; Li, Zhanxian
Tetrahedron, 2014 , vol. 70, # 3 p. 658 - 663
反应条件
1: 100 percent / 1.5 h / 60 - 70 °C 2: 16.5 g / KMnO4 / H2O / 3 h / 75 °C 3: HCl / Heating 4: 25 percent / Br2 / CHCl3 View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/92272 A1, 2011 ;
WO 2011/092272 A1
反应条件
1.1: 1.5 h / 90 °C 2.1: water; potassium permanganate / 4 h / 75 °C 2.2: pH 4 - 5 3.1: hydrogenchloride / methanol / 18 h / Reflux 4.1: bromine / chloroform / 40 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; FLOHR, Alexander; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew
Patent: WO2011/101304 A2, 2011 ;
WO 2011/101304 A2
反应条件
1.1: 50 h / 150 °C 2.1: sodium hydroxide; water / 1 h / 20 - 120 °C 2.2: pH ~ 4 - ~ 5 / Cooling with ice 3.1: chlorosulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 3.2: pH ~ 6 - ~ 11 4.1: sodium tetrahydroborate; methanol / 1 h / 20 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / methanol / 72 h 5.2: pH ~ 10 6.1: 18 h / 75 °C / Neat (no solvent) View Scheme
参考文献
AC IMMUNE S.A.; KROTH, Heiko; FROESTL, Wolfgang; PFEIFER, Andrea; MUHS, Andreas
Patent: WO2011/45383 A2, 2011 ;
反应条件
1: 65 percent / ethanol / 2 h / Heating 2: 29 percent / acetic acid / 3 h / 90 °C View Scheme
参考文献
Wang, Honggen; Wang, Yong; Liang, Dongdong; Liu, Lanying; Zhang, Jiancun; Zhu, Qiang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 25 p. 5678 - 5681
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
sulfuric acid; nitric acid T=50°C; 4 h;
参考文献
Ritter, H.; Licht, H. H.
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 2 p. 585 - 590
反应条件
nitric acid in conc. H2 SO4; sulfuric acid
参考文献
Merck and Co., Inc.
Patent: US5223499 A1, 1993 ;
US 5223499 A
反应条件
sulfuric acid; nitric acid
参考文献
Kulkarni, Santosh S.; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 2987 - 2991
