2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
sulfuric acid; nitric acid T=0 - 100°C;
参考文献
KARO BIO AB; ELSY, David
Patent: WO2005/42464 A1, 2005 ;
Location in patent: Page/Page column 32-33 ;
WO 2005/042464 A1
反应条件
sulfuric acid; nitric acid
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
sulfuric acid; nitric acid T=20 - 55°C; 2 h; Title compound not separated from byproducts;
参考文献
Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews III, Clarence W.; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 727 - 739
反应条件
sulfuric acid; nitric acid
参考文献
Kulkarni, Santosh S.; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 11 p. 2987 - 2991
反应条件
1: concentrated H2SO4; concentrated HNO3 2: sodium nitrite; concentrated aqueous hydrochloric acid / Diazotization 3: SnCl2; concentrated aqueous HCl View Scheme
参考文献
Parker; Shive
Journal of the American Chemical Society, 1947 , vol. 69, p. 63,66
反应条件
in acetone 6 h; Heating;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2005/68432 A1, 2005 ;
Location in patent: Page/Page column 201-202 ;
反应条件
1: 68 percent / ethyl acetate 2: 81 percent / glacial acetic acid / 80 - 100 °C 3: 69 percent / aq. NaHCO3 View Scheme
参考文献
Kovalenko; Kutrov; Filipchuk; Kornilov
Chemistry of Heterocyclic Compounds, 2002 , vol. 38, # 5 p. 590 - 597
反应条件
n-butyllithium 1.) OEt2, 90 min Room temp; 2.) 12 h 0 deg C; Yield given. Multistep reaction;
参考文献
Engelhardt, Lutz M.; Jacobsen, Geraldine E.; Junk, Peter C.; Raston, Colin L.; Skelton, Brian W.; White, Allan H.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1988 , p. 1011 - 1020
反应条件
in ethanol
0.166667 h; Heating;
参考文献
Mitchell, James A.; Reid, David H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 499 - 507
反应条件
triethylamine in dichloromethane
Ambient temperature;
参考文献
Goswami, Shyamaprosad; Ghosh, Kumaresh; Dasgupta, Swagata
Journal of Organic Chemistry, 2000 , vol. 65, # 7 p. 1907 - 1914
