2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
in tetrahydrofuran; pyridine
T=20°C; 12 h;
参考文献
Sun, Wen-Hua; Zhang, Wen; Gao, Tielong; Tang, Xiubo; Chen, Liyi; Li, Yan; Jin, Xianglin
Journal of Organometallic Chemistry, 2004 , vol. 689, # 5 p. 917 - 929
参考文献
ASTRAZENECA AB; ASTEX THERAPEUTICS
Patent: WO2006/65204 A1, 2006 ;
Location in patent: Page/Page column 140 ;
WO 2006/065204 A1
反应条件
1: 60 percent / glacial acetic acid / acetic acid / 4 h / Heating
2: 55 percent / 10percent aq. NaOH / 2 h
View Scheme
参考文献
Abdel-Aziz
Pakistan Journal of Scientific and Industrial Research, 1996 , vol. 39, # 5-8 p. 122 - 127
反应条件
1: Et3N / CH2Cl2
2: H2 / Pd-C / ethanol
View Scheme
参考文献
Goswami, Shyamaprosad; Ghosh, Kumaresh
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4503 - 4506
参考文献
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT
Patent: US4219649 A1, 1980 ;
反应条件
1.1: H2O / 3 h / cooling
1.2: 30 percent oleum; nitrobenzene / 0.5 h / 110 °C
1.3: 37 percent / NaOH / H2O / 1 h / pH 10 / cooling
2.1: 59 percent / SeO2; molecular sieves 4 Angstroem / dioxane / 2 h / Heating
View Scheme
参考文献
Chandler, Christopher J.; Deady, Leslie W.; Reiss, James A.; Tzimos, Vasilios
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1017 - 1019
反应条件
1: ethanol / 6 h / Heating
2: HNO3; H2SO4 / 2 h / -5 - 0 °C
View Scheme
参考文献
Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2790 - 2794
反应条件
1.1: ethylene glycol dimethyl ether / 20 °C
1.2: Heating
2.1: sulfuric acid; nitric acid / 0 - 5 °C
View Scheme
参考文献
Lopez-Martinez, Margarita; Salgado-Zamora, Hector; Campos-Aldrete, Ma. Elena; Trujillo-Ferrara, Jose G.; Correa-Basurto, Jose; Mexica-Ochoa, Carlos
Medicinal Chemistry Research, 2012 , vol. 21, # 4 p. 415 - 420
反应条件
in ethanol
2 h; Heating;
参考文献
Ikemoto, Tomomi; Wakimasu, Mitsuhiro
Heterocycles, 2001 , vol. 55, # 1 p. 99 - 108
反应条件
1: 0 °C
2: aq. sodium hydroxyde
3: 82 percent / cc. sulfuric acid, sodium sulfite / H2O / 4 h / Heating
View Scheme
参考文献
Okafor; Steenberg; Buckley
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 302 - 318
