2-氨基-6-甲基吡啶合成路线 （共 244 条）
参考文献
Ferrarini; Mori; Livi; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1053 - 1057
参考文献
Kaminski, James J.; Puchalski, Chester; Solomon, Daniel M.; Rizvi, Razia K.; Conn, David J.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1686 - 1700
反应条件
1.1: aq. HBr; Br2 / -20 °C
1.2: aq. NaNO2 / -20 °C
2.1: n-BuLi / -78 °C
2.2: Bu3SnCl
2.3: Pd(PPh3)4 / toluene / 110 °C
3.1: 48 percent / AIBN; NBS / benzene / Irradiation
View Scheme
参考文献
Weibel, Nicolas; Charbonniere, Loic J.; Guardigli, Massimo; Roda, Aldo; Ziessel, Raymond
Journal of the American Chemical Society, 2004 , vol. 126, # 15 p. 4888 - 4896
反应条件
in dimethyl sulfoxide
0.25 h; Microwave irradiation;
参考文献
Goswami, Shyamaprosad; Maity, Annada C.; Das, Nirmal K.; Sen, Debabrata; Maity, Sibaprasad
Synthetic Communications, 2009 , vol. 39, # 3 p. 407 - 415
反应条件
1: 79 percent / polyphosphoric acid / 5 h / 110 °C
2: 84 percent / diphenyl ether / 5 h / Heating
3: 82 percent / POCl3 / 1 h / Heating
View Scheme
参考文献
Ferrarini; Mori; Livi; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 4 p. 1053 - 1057
反应条件
iron(II) chloride in N,N-dimethyl-formamide
T=150°C; 7 h; regioselective reaction;
参考文献
Yan, Hao; Yang, Sizhuo; Gao, Xiai; Zhou, Kang; Ma, Chao; Yan, Rulong; Huang, Guosheng
Synlett, 2012 , vol. 23, # 20 p. 2961 - 2964
反应条件
anhydrous iron chloride
T=90°C; 4 h;
参考文献
Yan, Hao; Wang, Yuling; Pan, Congming; Zhang, Hao; Yang, Sizhuo; Ren, Xiaoyu; Li, Jian; Huang, Guosheng
European Journal of Organic Chemistry, 2014 , vol. 2014, # 13 p. 2754 - 2763
反应条件
sodium amide; N,N-dimethyl-aniline
T=200°C;
参考文献
Schering A.G.
Patent: DE663891 , 1936 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 357
反应条件
in various solvent(s)
30 h; Heating;
参考文献
Bianchi; Butti; Rossi; et al.
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 6 p. 495 - 500
反应条件
2: lead (II)-acetate; aq.-ethanolic NaOH
View Scheme
参考文献
Clemo et al.
Journal of the Chemical Society, 1954 , p. 2693,2697
