2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
diethyl ether; sodium amide
参考文献
Feist; Kuklinski
Archiv der Pharmazie (Weinheim, Germany), 1936 , vol. 274, p. 425,435
反应条件
triethylamine in chloroform
T=20°C; 4 h;
参考文献
Maria, Dolores Santa; Farran, M. Angeles; Garcia, M. Angeles; Pinilla, Elena; Torres, M. Rosario; Elguero, Jose; Claramunt, Rosa M.
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6780 - 6788
参考文献
Singha, Netai C.; Sathyanarayana
Journal of Molecular Structure, 1997 , vol. 403, # 1-2 p. 123 - 135
反应条件
1: 1 h / 130 °C
2: H2SO4 / 100 °C
View Scheme
参考文献
Leonard, Joseph Thomas; Gangadhar, Revuluri; Gnanasam, Sundararaj Kishore; Ramachandran, Somasundaram; Saravanan, Muniyandy; Sridhar, Seshaiah Krishnan
Biological and pharmaceutical bulletin, 2002 , vol. 25, # 6 p. 798 - 802
反应条件
1.1: propan-2-ol / Heating
1.2: 81 percent / hydroxylamine hydrochloride / propan-2-ol / 50 °C
2.1: 91 percent / trifluoroacetic anhydride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Huntsman, Elliott; Balsells, Jaume
European Journal of Organic Chemistry, 2005 , # 17 p. 3761 - 3765
反应条件
1: ethanol / 0.17 h / 40 °C
2: aq. NaOH / 2 h / Heating
View Scheme
参考文献
Li, Zhe; Silber, B. Michael; Rao, Satish; Gever, Joel R.; Bryant, Clifford; Gallardo-Godoy, Alejandra; Dolghih, Elena; Widjaja, Kartika; Elepano, Manuel; Jacobson, Matthew P.; Prusiner, Stanley B.; Renslo, Adam R.
ChemMedChem, 2013 , vol. 8, # 5 p. 847 - 857
反应条件
in sodium hydroxide; ethanol
参考文献
Press, Neil John; Taylor, Roger John
Patent: US2004/53982 A1, 2004 ;
反应条件
1: With benzoyl chloride in acetone
1 h; Heating;
2: With sodium hydroxide in water
Heating;
参考文献
Narayana; Vijaya Raj; Ashalatha; Kumari, N. Suchetha; Sarojini
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 867 - 872
反应条件
1: 1) 48percent HBr, Br2 2) NaNO2 / 1) -15 to -10 deg C, 30 min 2) water, 90 min
2: 1) Raney Nickel 2) water / 1) toluene, 22 h, reflux 2) 2 h, 40 deg C
3: 25 percent / NBS, AIBN, 62percent HBr, Br2 / CCl4 / 4 h / Heating
4: 20 percent / DMSO / 8 h / 150 °C
View Scheme
参考文献
Voegtle, Fritz; Hochberg, Robert; Kochendoerfer, Frank; Windscheif, Paul-Michael; Volkmann, Martin; Jansen, Martin
Chemische Berichte, 1990 , vol. 123, # 11 p. 2181 - 2185
反应条件
1.1: 50 h / 150 °C
2.1: sodium hydroxide; water / 1 h / 20 - 120 °C
2.2: pH ~ 4 - ~ 5 / Cooling with ice
View Scheme
参考文献
AC IMMUNE S.A.; KROTH, Heiko; FROESTL, Wolfgang; PFEIFER, Andrea; MUHS, Andreas
Patent: WO2011/45383 A2, 2011 ;
