2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
1.1: HBr; bromine / 2 h / -20 °C 1.2: 77 percent / sodium nitrite / H2O / 1.75 h / -20 - 15 °C 2.1: 50 percent / sodium formate; benzyltriethylammonium chloride; NaOH / Pd/C / H2O / 216 h / Heating View Scheme
参考文献
Laitinen, Riitta H.; Csoban, Katalin; Pursiainen, Jouni; Huuskonen, Juhani; Rissanen, Kari
Acta Chemica Scandinavica, 1997 , vol. 51, # 4 p. 462 - 469
反应条件
sulfuric acid; sodium nitrite Diazotization.Erwaermen der Diazoniumsalz-Loesung;
参考文献
Seide
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1920 , vol. 50, p. 536
Chem. Zentralbl., 1923 , vol. 94, # III p. 1022
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin in dichloromethane T=-10 - 20°C; 2 - 3 h; Product distribution / selectivity;
参考文献
ANORMED INC.
Patent: WO2007/22371 A2, 2007 ;
Location in patent: Page/Page column 49-50 ;
WO 2007/022371 A2
反应条件
bromine in acetic acid T=20°C; 1 h;
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Dunn, A. D.; Currie, A.; Hayes, L. E.
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 3 p. 369 - 374
反应条件
pyridine hydrogenfluoride; sodium nitrite 1.) O deg C, 20 min, 2.) 0 deg C, 1 h;
参考文献
Yoneda; Fukuhara
Tetrahedron, 1996 , vol. 52, # 1 p. 23 - 36
反应条件
1: 90 percent / ethanol / 16 h / Heating 2: 71 percent / diphenyl ether / 0.5 h / Heating 3: 72 percent / K2CO3 / dimethylformamide / 90 - 100 °C 4: 91 percent / aq. NaOH / tetrahydrofuran / 8 h / Heating View Scheme
参考文献
Synthesis, , # 14 art. no. P04405SS, p. 2315 - 2320
反应条件
1: concentrated H2SO4; concentrated HNO3 2: sodium nitrite; aqueous hydrochloric acid / Diazotization View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
N-chloro-succinimide in hexane; N,N-dimethyl-formamide
参考文献
State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University and The University of Oregon, Eugene Oregon; The Regents of the University of California; ACEA Pharmaceuticals, Inc.
Patent: US5620978 A1, 1997 ;
US 5620978 A
反应条件
1: aqueous H2SO4; bromine 2: aqueous sulfuric acid; sodium nitrite / Diazotization View Scheme
参考文献
Adams; Schrecker
Journal of the American Chemical Society, 1949 , vol. 71, p. 1186,1191
