2-氨基-6-甲基吡啶合成路线 （共 244 条）
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 6 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 10 p. 3563 - 3570
反应条件
in tert-butyl alcohol
参考文献
Ji, Haitao; Li, Huiying; Martasek, Pavel; Roman, Linda J.; Poulos, Thomas L.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 779 - 797
反应条件
triethylamine in chloroform T=-5 - 0°C; 3.5 h; Product distribution / selectivity;
参考文献
Nippon Soda Co., Ltd.
Patent: US2013/5981 A1, 2013 ;
Location in patent: Page/Page column 5-6 ;
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate T=-15 - -5°C; 2.5 h; Product distribution / selectivity;
参考文献
US2013/5981 A1, ;
Page/Page column 5 ;
参考文献
SmithKline Beecham Corporation
Patent: US6069158 A1, 2000 ;
反应条件
1: sulfuric acid; nitric acid 2: hydrogenchloride; sodium nitrite 3: phosphorus pentachloride; trichlorophosphate 4: palladium on carbon; hydrogen 5: tetrafluoroboric acid; EtO-NO 6: iodine; potassium acetate / acetic anhydride 7: ozone View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
triethylamine in dichloromethane T=20°C; 24 h; Inert atmosphere;
参考文献
Fray, M. Jonathan; Gillmore, Adam T.; Glossop, Melanie S.; McManus, David J.; Moses, Ian B.; Praquin, Celine F.B.; Reeves, Keith A.; Thompson, Lisa R.
Organic Process Research and Development, 2010 , vol. 14, # 1 p. 263 - 271
反应条件
1: 25 g / Br2; AcONa; AcOH / 1 h / 15 °C 2: HNO3; H2SO4 / 0 - 60 °C 3: 90 percent / hydrazine hydrate; Zn / butan-1-ol / Heating 4: 90.5 percent / 4 h / 170 - 180 °C View Scheme
参考文献
Yutilov; Svertilova; Minkina; Kirillova; Smolyar
Russian Journal of Applied Chemistry, 2005 , vol. 78, # 5 p. 787 - 790
反应条件
1: aq. NaHCO3 / CHCl3 / 1 h / 20 °C 2: 4-aminomethylpiperidine / CHCl3 / 12 h / 20 °C View Scheme
参考文献
Kulkarni, Santosh S.; Nightingale, Barbara; Dersch, Christina M.; Rothman, Richard B.; Newman, Amy Hauck
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3371 - 3375
反应条件
1.2: 75 °C 2.1: sulfuric acid / Reflux 3.1: sodium tetrahydroborate; calcium chloride / ethanol / 2 h / 0 °C / Inert atmosphere View Scheme
参考文献
Ulrich, Sebastien; Petitjean, Anne; Lehn, Jean-Marie
European Journal of Inorganic Chemistry, 2010 , # 13 p. 1913 - 1928
