(R)-1-((R)-2,2-二甲基-1,3-二噁戊环-4-基)丙-2-烯-1-醇合成路线 （共 13 条）
反应条件
ytterbium(III) triflate in tetrahydrofuran
T=-78°C; 2.5 h; Yield given. Yields of byproduct given;
参考文献
Molander, Gary A.; Estevez-Braun, Ana Maria
Bulletin de la Societe Chimique de France, 1997 , vol. 134, # 3-4 p. 275 - 282
反应条件
lithium aluminium tetrahydride; sodium hexamethyldisilazane in tetrahydrofuran
T=20°C; 8 h;
参考文献
Chandrasekhar; Raza, Abbas; Takhi, Mohamed
Tetrahedron Asymmetry, 2002 , vol. 13, # 4 p. 423 - 428
反应条件
1: 76 percent / Mg; CuI / tetrahydrofuran
2: 95 percent / NaH; HMPA
View Scheme
参考文献
Williams; Clark; Emde; Berliner
Organic letters, 2000 , vol. 2, # 19 p. 3023 - 3026
反应条件
zinc in ethanol
2 h; Heating; Yield given;
参考文献
Lu, Wei; Zheng, Guangrong; Cai, Junchao
Synlett, 1998 , # 7 p. 737 - 738
反应条件
1: 72 percent / methanol / 6 h / 20 °C
2: 52 percent / sodium hexamethyldisilazide; LiAlH4 / tetrahydrofuran / 8 h / 20 °C
View Scheme
参考文献
Chandrasekhar; Raza, Abbas; Takhi, Mohamed
Tetrahedron Asymmetry, 2002 , vol. 13, # 4 p. 423 - 428
反应条件
1: pyridine / Ambient temperature
2: NaI / acetone / 24 h / Heating
3: Zn / ethanol / 2 h / Heating
View Scheme
参考文献
Lu, Wei; Zheng, Guangrong; Cai, Junchao
Synlett, 1998 , # 7 p. 737 - 738
反应条件
1: NaI / acetone / 24 h / Heating
2: Zn / ethanol / 2 h / Heating
View Scheme
参考文献
Lu, Wei; Zheng, Guangrong; Cai, Junchao
Synlett, 1998 , # 7 p. 737 - 738
反应条件
1: 99 percent / pyridine / 18 h
2: water / 20 °C / porcine pancreatic lipase, phosphate buffer pH 5 (maintained with 0.1 N NaOH)
3: 94 percent / aq. K2CO3 / methanol / 0.25 h / 20 °C
4: 97 percent / LiAlH4 / diethyl ether / 2 h / 20 °C
View Scheme
参考文献
Mulzer, Johann; Greifenberg, Stefan; Beckstett, Anne; Gottwald, Matthias
Liebigs Annalen der Chemie, 1992 , # 11 p. 1131 - 1136
反应条件
1: water / 20 °C / porcine pancreatic lipase, phosphate buffer pH 5 (maintained with 0.1 N NaOH)
2: 94 percent / aq. K2CO3 / methanol / 0.25 h / 20 °C
3: 97 percent / LiAlH4 / diethyl ether / 2 h / 20 °C
View Scheme
参考文献
Mulzer, Johann; Greifenberg, Stefan; Beckstett, Anne; Gottwald, Matthias
Liebigs Annalen der Chemie, 1992 , # 11 p. 1131 - 1136
反应条件
1: methanol; (S,S)-[CuCl(C10H6N3(phenyl)2C6H2(CH3)2C(CH3)3)]; sodium t-butanolate / diethyl ether / 16 h / -55 °C
2: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; diethyl ether; water / 1 h / -55 - 20 °C
View Scheme
参考文献
Park, Jin Kyoon; McQuade, D. Tyler
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2717 - 2721
