R-1,1'-联-2-萘酚合成路线 （共 56 条）
反应条件
bromine in dichloromethane T=-78°C; Inert atmosphere;
参考文献
Bunzen, Jens; Bruhn, Torsten; Bringmann, Gerhard; Luetzen, Arne
Journal of the American Chemical Society, 2009 , vol. 131, p. 3621 - 3630
反应条件
sodium hydroxide; Raney Ni-Al alloy T=90°C; 6 h; Title compound not separated from byproducts;
参考文献
Guo; Ding
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10061 - 10064
反应条件
sodium hydroxide; Raney Ni-Al alloy T=90°C; 6 h; Title compound not separated from byproducts;
参考文献
Guo; Ding
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10061 - 10064
反应条件
sodium hydroxide; Raney Ni-Al alloy T=90°C; 6 h; Title compound not separated from byproducts;
参考文献
Guo; Ding
Tetrahedron Letters, 2000 , vol. 41, # 51 p. 10061 - 10064
反应条件
1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 0 °C 2: 2.) TBAF / 1.) pyridine, 0 deg C, 30 min, RT, 1 h; 2.) pyridine, THF, RT, 7 h 3: K2CO3 / dimethylformamide / 6 h / Ambient temperature 4: 90 percent Spectr. / Pd(OAc)2, bis(2-(diphenylphosphino)phenyl) ether, 4 Angstroem molecular sieves, Et3N, Cs2CO3 / toluene / 18 h / 110 °C 5: aq. HCl / tetrahydrofuran; ethanol / 1 h 6: NH4HCO2 / 20 percent Pd(OH)2/C / tetrahydrofuran; propan-2-ol / 1 h / Heating View Scheme
参考文献
Singer, Robert A.; Buchwald, Stephen L.
Tetrahedron Letters, 1999 , vol. 40, # 6 p. 1095 - 1098
反应条件
1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 0 °C 2: 2.) TBAF / 1.) pyridine, 0 deg C, 30 min, RT, 1 h; 2.) pyridine, THF, RT, 7 h 3: K2CO3 / dimethylformamide / 6 h / Ambient temperature 4: 90 percent Spectr. / Pd(OAc)2, bis(2-(diphenylphosphino)phenyl) ether, 4 Angstroem molecular sieves, Et3N, Cs2CO3 / toluene / 18 h / 110 °C 5: aq. HCl / tetrahydrofuran; ethanol / 1 h 6: NH4HCO2 / 20 percent Pd(OH)2/C / tetrahydrofuran; propan-2-ol / 1 h / Heating View Scheme
参考文献
Singer, Robert A.; Buchwald, Stephen L.
Tetrahedron Letters, 1999 , vol. 40, # 6 p. 1095 - 1098
