反应条件
1: SOCl2, DMF / Heating 3: 74 percent / SOCl2 / benzene; CH2Cl2 / 0 °C 4: 1.) NaH / 1.) DMF, 50 deg C, 3 h, 2.) 50 deg C, 5 h 5: 1.) Mg / 1.) Et2O <dibromoethane>, benzene, reflux, 2.) reflux, 3.25 h 6: 2.) aqueous 20 percent NaOH / 1.) 12 h, 25 deg C, 2.) MeOH, 24 h, reflux 7: BH3*THF / tetrahydrofuran / 1.a) 10 min, 0 deg C, b) 1 h, 25 deg C, 2.) THF/H2O = 2:1, 15 min, 25 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, # 25 p. 4930 - 4943
