3-吡咯烷-1-苯甲酸甲酯合成路线 （共 4 条）
反应条件
caesium carbonate; P(i-BuNCH2)3CMe; palladium diacetate in toluene T=80°C; Buchwald-Hartwig amination reaction;
参考文献
Iowa State University Research Foundation, Inc.
Patent: US7385058 B1, 2008 ;
Location in patent: Page/Page column 25-26; 34-35 ;
反应条件
1: 88 percent / acetyl chloride / 1 h / Heating 2: 1.) NaH, 2.) KI / 1.) DMF, 0 deg C, 14 h, 2.) DMF, 80 deg C, 72 h View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
sodium hydride; potassium iodide 1.) DMF, 0 deg C, 14 h, 2.) DMF, 80 deg C, 72 h; Yield given. Multistep reaction;
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
lithium hydroxide in 1,4-dioxane; water 1.) RT, 10 min, 2.) 40 deg C, 30 min;
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
