(2-羟基苯基)-(4-甲氧基苯基)甲酮合成路线 （共 20 条）
反应条件
methanesulfonic acid; carbon
T=80°C; Friedel-Crafts acylation; 1 h;
参考文献
Sarvari, Mona Hosseini; Sharghi, Hashem
Helvetica Chimica Acta, 2005 , vol. 88, # 8 p. 2282 - 2287
反应条件
1: With BBr3*Me2S complex in dichloromethane
T=0 - 20°C; 3 h;
2: With water in dichloromethane
T=0°C;
参考文献
Aventis Pharma Deutschland GmbH
Patent: US2005/14704 A1, 2005 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1: methoxybenzene With polymer-supported phenyliodine(III) diacetate; sulfuric acid in acetic acid
T=20°C; Substitution; 20 h;
2: 2-methyl-benzyl alcohol With sodium carbonate; lithium chloride; palladium dichloride in N,N-dimethyl-formamide
T=60 - 70°C; Substitution; 6 h;
参考文献
Chen
Synlett, 2000 , # 8 p. 1175 - 1177
反应条件
oxygen; sodium hydrogencarbonate; palladium(II) chloride bis(benzonitrile) complex; copper dichloride in N,N-dimethyl-formamide
T=60°C; P=760.051 Torr; 11 h;
参考文献
Weng, Fei; Wang, Chengming; Xu, Bin
Tetrahedron Letters, 2010 , vol. 51, # 19 p. 2593 - 2596
反应条件
sodium carbonate; lithium chloride; palladium dichloride in N,N-dimethyl-formamide
T=100°C; 10 h; Inert atmosphere;
参考文献
Moure, Maria J.; Sanmartin, Raul; Dominguez, Esther
Angewandte Chemie - International Edition, 2012 , vol. 51, # 13 p. 3220 - 3224
反应条件
sodium hydroxide; RhCl(1,3-diisopropyl-tetrahydropyrimidin-2-ylidene)(COD) in ethylene glycol dimethyl ether; water
T=80°C; 14 h; Product distribution; Further Variations:Catalysts;
参考文献
Imlinger, Nicolas; Mayr, Monika; Wang, Dongren; Wurst, Klaus; Buchmeiser, Michael R.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1836 - 1843
反应条件
sodium carbonate; lithium chloride; palladium dichloride in N,N-dimethyl-formamide
T=40°C; Arylation; 5 h;
参考文献
Xia, Min; Chen, ZhenChu
Synthetic Communications, 2000 , vol. 30, # 3 p. 531 - 536
反应条件
sodium carbonate; lithium chloride; palladium dichloride in N,N-dimethyl-formamide
T=40°C; Arylation; 5 h;
参考文献
Xia, Min; Chen, ZhenChu
Synthetic Communications, 2000 , vol. 30, # 3 p. 531 - 536
反应条件
n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-70°C; 2 h;
参考文献
Horne, Stephen; Rodrigo, Russell
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4520 - 4522
反应条件
tetracarbonylbis(μ-chloro)dirhodium(I); di-tert-butyl peroxide in chlorobenzene
T=160°C; 24 h; Inert atmosphere;
参考文献
Rao, Honghua; Li, Chao-Jun
Angewandte Chemie - International Edition, 2011 , vol. 50, # 38 p. 8936 - 8939
