5-甲基-2-苯基-1,3--恶唑-4-甲酸合成路线 (共 30 条)
反应条件
1: CaCO3; chlorine 2: methanol. NaOH 3: sodium acetate / 160 - 165 °C 4: aqueous NaOH View Scheme
参考文献
Chemische Berichte, , vol. 90, p. 1455,1464
反应条件
Erwaermen des Reaktionsprodukts mit wss.-aethanol. NaOH;
参考文献
Journal of the Chemical Society, , p. 1085,1087
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wipf, Peter; Cunningham, April; Rice, Robert L.; Lazo, John S.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 1 p. 165 - 177
参考文献
Allan,A.W.; Walter,B.H.
Journal of the Chemical Society [Section] C: Organic, 1968 , p. 1397 - 1399
反应条件
ammonium hydroxide T=190°C;
参考文献
Cornforth; Huang
Journal of the Chemical Society, 1948 , p. 1969
参考文献
Tarzia,G. et al.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 263 - 270
反应条件
1: SO2Cl / dimethylformamide
2: (i) CdCl2, Et2O, (ii) /BRN= 165312/, benzene
3: diethyl ether
View Scheme
参考文献
Padwa,A. et al.
Journal of the American Chemical Society, 1975 , vol. 97, p. 6484 - 6491
参考文献
Padwa,A. et al.
Journal of the American Chemical Society, 1975 , vol. 97, p. 6484 - 6491
反应条件
1: SOCl2 / dimethylformamide
2: NH3
View Scheme
参考文献
Tarzia,G. et al.
European Journal of Medicinal Chemistry, 1976 , vol. 11, p. 263 - 270
参考文献
Cornforth
Chem. Penicillin, <Princeton 1949>, S. 688, 706
Full Text Show Details
Cornforth; Huang
Journal of the Chemical Society, 1948 , p. 1969