2-(2-溴乙基)-1,3-二恶烷合成路线 （共 57 条）
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 36, # 4 p. 833 - 837
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 4 p. 906 - 910
反应条件
chloro-trimethyl-silane; sodium bromide T=22°C; 1.5 h;
参考文献
Synthetic Communications, , vol. 15, # 2 p. 87 - 90
反应条件
toluene-4-sulfonic acid in benzene 4 h; Heating; Yield given;
参考文献
Synthetic Communications, , vol. 20, # 8 p. 1175 - 1179
反应条件
1: 90 percent / sodium azide, tetra-n-hexylammonium bromide / H2O / 2 h 2: 1.) Ph3P, 2.) H2O / 1) THF, 3 h, below 40 deg C, 20 deg C (1 h); 2) 1 h, 20 deg C 3: 57 percent / triethylamine / 4.5 h / 75 °C View Scheme
参考文献
Gribble, Gordon W.; Switzer, Frank L.
Synthetic Communications, 1987 , vol. 17, # 4 p. 377 - 384
反应条件
in N-methyl-acetamide; dichloromethane; water
参考文献
Gensia, Inc.
Patent: US5775329 A1, 1998 ;
反应条件
sodium amide; 1,1,1,3,3,3-hexamethyl-disilazane in xylene 1.) reflux, 5 h; r.t., 2 h, 2.) reflux, 4 h;
参考文献
Buchbauer, G.; Spreitzer, H.; Zechmeister-Machhart, F.; Haunschmidt, C.; Troescher, F.
Monatshefte fuer Chemie, 1996 , vol. 127, # 6/7 p. 747 - 754
反应条件
N,N'-dimethyl-N,N'-propyleneurea; water; pyridinium p-toluenesulfonate 1.) THF, 2.) acetone, reflux; Multistep reaction;
参考文献
Berk, Scott C.; Grossman, Robert B.; Buchwald, Stephen L.
Journal of the American Chemical Society, 1994 , vol. 116, # 19 p. 8593 - 8601
反应条件
T=20 - 110°C; Michaelis-Arbuzov reaction; 24 h; Inert atmosphereneat (no solvent);
参考文献
Camper, Nicolas; Scott, Christopher J.; Migaud, Marie E.
New Journal of Chemistry, 2010 , vol. 34, # 5 p. 949 - 955
反应条件
T=20 - 110°C; Michaelis-Arbuzov reaction; 24 h; Inert atmosphereneat (no solvent);
参考文献
Camper, Nicolas; Scott, Christopher J.; Migaud, Marie E.
New Journal of Chemistry, 2010 , vol. 34, # 5 p. 949 - 955
反应条件
1: diethyl malonate With sodium ethanolate in ethanol T=55°C; Metallation; 2: 2-(1,3-dioxa-2-cyclopentyl)-ethyl bromide in ethanol T=55°C; Alkylation; 0.416667 h;
参考文献
Kanoh; Ishihara; Yamamoto; Murai
Synthesis, 2000 , # 13 p. 1878 - 1893
