6-甲氧基-1,2,3,4-四氢吖啶-9-胺合成路线 （共 7 条）
反应条件
ammonia; phenol T=180 - 190°C; 4 h;
参考文献
Del Giudice; Borioni; Mustazza; Gatta; Meneguz; Volpe
Farmaco, 1996 , vol. 51, # 11 p. 693 - 698
反应条件
silica gel; toluene-4-sulfonic acid microwave irradiation;
参考文献
Khalilzadeh, Mohammad A.; Hosseini, Abolfazl; Tajbakhsh', Mahmoud
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 3 p. 535 - 538
反应条件
1: 55 percent / POCl3 / 2 h / Heating 2: 50 percent / NH3; phenol / 4 h / 125 - 130 °C View Scheme
参考文献
Recanatini, Maurizio; Cavalli, Andrea; Belluti, Federica; Piazzi, Lorna; Rampa, Angela; Bisi, Alessandra; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Bartolini, Manuela; Cavrini, Vanni
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2007 - 2018
反应条件
1: 55 percent / POCl3 / 2 h / Heating 2: 50 percent / NH3; phenol / 4 h / 125 - 130 °C View Scheme
参考文献
Recanatini, Maurizio; Cavalli, Andrea; Belluti, Federica; Piazzi, Lorna; Rampa, Angela; Bisi, Alessandra; Gobbi, Silvia; Valenti, Piero; Andrisano, Vincenza; Bartolini, Manuela; Cavrini, Vanni
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2007 - 2018
反应条件
1: p-TsOH*H2O / toluene / 8 h / Heating 2: diphenyl ether / 0.5 h / Heating 3: 92 percent / POCl3 / 1 h / Heating 4: 78 percent / NH3, phenol / 4 h / 180 - 190 °C View Scheme
参考文献
Del Giudice; Borioni; Mustazza; Gatta; Meneguz; Volpe
Farmaco, 1996 , vol. 51, # 11 p. 693 - 698
反应条件
1: p-TsOH*H2O / toluene / 8 h / Heating 2: diphenyl ether / 0.5 h / Heating 3: 92 percent / POCl3 / 1 h / Heating 4: 78 percent / NH3, phenol / 4 h / 180 - 190 °C View Scheme
参考文献
Del Giudice; Borioni; Mustazza; Gatta; Meneguz; Volpe
Farmaco, 1996 , vol. 51, # 11 p. 693 - 698
反应条件
1: 92 percent / POCl3 / 1 h / Heating 2: 78 percent / NH3, phenol / 4 h / 180 - 190 °C View Scheme
参考文献
Del Giudice; Borioni; Mustazza; Gatta; Meneguz; Volpe
Farmaco, 1996 , vol. 51, # 11 p. 693 - 698
