3-乙酰基-4-氧代戊酸乙酯合成路线 （共 18 条）
反应条件
1: acetylacetone With sodium hydride in tetrahydrofuran T=0°C; 1 h; 2: ethyl bromoacetate in tetrahydrofuran T=0°C; 16 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2008/141020 A1, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/141020 A1
反应条件
1: With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: in tetrahydrofuran 18 h; RefluxInert atmosphere;
参考文献
Synthetic Communications, , vol. 44, # 1 p. 42 - 48
反应条件
1: acetylacetone With sodium hydride in tetrahydrofuran; mineral oil T=0°C; 1 h; 2: ethyl bromoacetate in tetrahydrofuran; mineral oil 18 h; Overall yield = 78 percent; Overall yield = 2.9 g;
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 6 p. 2773 - 2788
反应条件
potassium carbonate; caesium carbonate in dichloromethane 12 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 20, # 13 p. 2075 - 2080
参考文献
Journal of the American Chemical Society, , vol. 31, p. 668
反应条件
1: acetylacetone With sodium 2: chloroacetic acid ethyl ester
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, p. S258 - S258
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, p. S250 - S250
反应条件
water; benzene Reinigung ueber die Kupfer(II)-Verbindung;
参考文献
Suomen Kemistilehti B, , vol. 28, p. 87,90
参考文献
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 130, p. 1193,1194
Annales de Chimie (Cachan, France), , vol. <7> 26, p. 308
反应条件
1: N2H4 2: NaOH View Scheme
参考文献
Rackham, Mark D.; Brannigan, James A.; Rangachari, Kaveri; Meister, Stephan; Wilkinson, Anthony J.; Holder, Anthony A.; Leatherbarrow, Robin J.; Tate, Edward W.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 6 p. 2773 - 2788
参考文献
March
Annales de Chimie (Cachan, France), 1902 , vol. <7> 26, p. 305
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1901 , vol. 132, p. 697
