3-甲基-2-硝基苯甲腈合成路线 (共 11 条)
反应条件
trifluoroacetic anhydride in dichloromethane T=0°C; 1 h;
参考文献
PFIZER INC.; DOUNAY, Amy Beth; HELAL, Christopher John; TUTTLE, Jamison Bryce; VERHOEST, Patrick Robert
Patent: WO2012/73146 A1, 2012 ;
Location in patent: Page/Page column 37 ;
WO 2012/073146 A1
反应条件
1.1: triethylamine; isopropyloxycarbonylchloride / dichloromethane / 1 h / 0 °C 1.2: 0.5 h / 0 °C 2.1: trifluoroacetic anhydride / dichloromethane / 1 h / 0 °C View Scheme
参考文献
PFIZER INC.; DOUNAY, Amy Beth; HELAL, Christopher John; TUTTLE, Jamison Bryce; VERHOEST, Patrick Robert
Patent: WO2012/73146 A1, 2012 ;
WO 2012/073146 A1
参考文献
Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
参考文献
Macovski; Georgescu
Bull. Sect. Sci. Acad. Roum., 1946 , vol. 28, p. 354,359
反应条件
(i) H2, Pd-C, (ii) aq. NaOH; Multistep reaction;
参考文献
Juergens
Chemische Berichte, 1907 , vol. 40, p. 4413
反应条件
(NH4)2S T=100°C; im Einschlussrohr;
参考文献
Juergens
Chemische Berichte, 1907 , vol. 40, p. 4413
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Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
参考文献
Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
反应条件
palladium in ethanol; hexane
参考文献
ICI Americas Inc.
Patent: US4975435 A1, 1990 ;
参考文献
Gabriel; Thieme
Chemische Berichte, 1919 , vol. 52, p. 1083
反应条件
1: (i) H2, Pd-C, (ii) aq. NaOH 2: (i) NaNO2, aq. H2SO4, (ii) KI View Scheme
参考文献
Gore,P.H. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2940 - 2948