3-苄基-3,9-二氮杂螺环[5.5]十一烷合成路线 （共 7 条）
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in xylene T=0 - 127°C; 2: With water; sodium hydroxide in xylene T=0°C; 0.583333 h;
参考文献
NEUROGEN CORPORATION; XU, Yuelian; XIE, Linghong; HAN, Bingsong; MAYNARD, George D.; CHENARD, Bertrand, L.; STAAB, Andrew J.
Patent: WO2009/97405 A2, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 16 h; Reflux;
参考文献
Shionogi and Co., Ltd.; HISAKAWA, Shinya; HASEGAWA, Yasushi; AOKI, Toshiaki; KUSANO, Hiroki; SANO, Masayuki; SATO, Jun; YAMAWAKI, Kenji
Patent: EP2557082 A1, 2013 ;
Location in patent: Paragraph 0248; 0251 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reflux; 2: With water in tetrahydrofuran T=20°C;
参考文献
WO2009/97405 A2, ;
Page/Page column 16 ;
反应条件
1.1: ammonia / methanol / 4.8 h / 0 - 4 °C 2.1: sulfuric acid / water / 16 h / |Reflux 2.2: 20 °C / pH 8 3.1: lithium aluminium tetrahydride / diethyl ether / 16 h / |Reflux View Scheme
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 94 ;
WO 2007/030061 A1
反应条件
1: With acetic acid in dichloromethane T=0°C; 0.5 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=20°C;
参考文献
NEUROGEN CORPORATION
Patent: WO2007/140383 A2, 2007 ;
Location in patent: Page/Page column 53 ;
WO 2007/140383 A2
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 94 ;
WO 2007/030061 A1
