2-苯基-1H-吲哚-5-羧酸甲酯合成路线 （共 13 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride in water
参考文献
ASTRAZENECA AB
Patent: WO2009/64251 A1, 2009 ;
Location in patent: Page/Page column 142 ;
WO 2009/064251 A1
反应条件
copper(l) iodide; N,N,N',N'-tetramethylguanidine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=50°C;
参考文献
AstraZeneca AB
Patent: US2009/131468 A1, 2009 ;
Location in patent: Page/Page column 67 ;
US 20090131468 A1
反应条件
potassium carbonate; L-proline; copper(I) bromide in dimethyl sulfoxide
T=100°C; 3 h; Inert atmosphere;
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252
反应条件
dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; potassium phosphate; palladium diacetate in toluene
T=100°C; 1.5 h;
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
copper(l) iodide; TMG; bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane
T=80°C; 18 h;
参考文献
Fagnola, Maria Chiara; Candiani, Ilaria; Visentin, Giuseppina; Cabri, Walter; Zarini, Franco; Mongelli, Nicola; Bedeschi, Angelo
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2307 - 2310
反应条件
[Rh(coe)2Cl]2; tris(4-trifluoromethylphenyl)phosphine in 1,4-dioxane
T=120°C;
参考文献
Wang, Xiang; Lane, Benjamin S.; Sames, Dalibor
Journal of the American Chemical Society, 2005 , vol. 127, # 14 p. 4996 - 4997
反应条件
copper(l) iodide; potassium carbonate; L-proline in N,N-dimethyl-formamide
T=80°C; 24 h;
参考文献
Liu, Feng; Ma, Dawei
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 4844 - 4850
反应条件
potassium acetate; palladium diacetate; bis(1,1-diphenylphosphino)methane in water
T=110°C; 24 h; regioselective reaction;
参考文献
Joucla, Lionel; Batail, Nelly; Djakovitch, Laurent
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 17 p. 2929 - 2936
反应条件
1: 6.2 g / acetic acid
3: 95 percent / tetramethylguanidine, CuI / Pd(Ph3P)2Cl2 / dioxane / 18 h / 80 °C
View Scheme
参考文献
Fagnola, Maria Chiara; Candiani, Ilaria; Visentin, Giuseppina; Cabri, Walter; Zarini, Franco; Mongelli, Nicola; Bedeschi, Angelo
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2307 - 2310
反应条件
2: 95 percent / tetramethylguanidine, CuI / Pd(Ph3P)2Cl2 / dioxane / 18 h / 80 °C
View Scheme
参考文献
Fagnola, Maria Chiara; Candiani, Ilaria; Visentin, Giuseppina; Cabri, Walter; Zarini, Franco; Mongelli, Nicola; Bedeschi, Angelo
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2307 - 2310
