Tundo, Pietro; Venturello, Paolo; Angeletti, Enrico
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2159 - 2162
1: n-butyl methanesulphonate With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: With diethyl chlorophosphate in tetrahydrofuran; hexane
T=-78 - 50°C; 1.5 h;
3: 5-Bromothiophene-2-carboxaldehyde With n-butyllithium; water
more than 3 stages;
参考文献
ASTRAZENECA AB
Patent: WO2007/8143 A1, 2007 ;
Location in patent: Page/Page column 61 ;
WO 2007/008143 A1
Tundo, Pietro; Venturello, Paolo; Angeletti, Enrico
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2159 - 2162