(S)-1-苄基-4-羟基-2-吡咯烷酮合成路线 （共 12 条）
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate P=760.051 Torr; 12 h;
参考文献
Tetrahedron Letters, , vol. 54, # 21 p. 2637 - 2640
反应条件
1: With hydrogenchloride; methanol 2 h; 2: With sodium hydrogencarbonate in methanol T=0°C;
参考文献
Wee, Andrew G. H.; Fan, Gao-Jun; Bayirinoba, Hypolite M.
Journal of Organic Chemistry, 2009 , vol. 74, # 21 p. 8261 - 8271
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: methanol in tetrahydrofuran; hexane T=-78 - 0°C; Carbonylation;
参考文献
Huang, Pei Qiang; Zheng, Xiao; Li Wang, Shi; Liang Ye, Jian; Ren Jin, Li; Chen, Zhong
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3309 - 3317
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: methyl iodide in tetrahydrofuran; hexane T=-78 - 0°C; Addition;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: acetone in tetrahydrofuran; hexane T=-78 - 0°C; Carbonylation;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: cyclohexanone in tetrahydrofuran; hexane T=-78 - 0°C; Addition;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: benzaldehyde in tetrahydrofuran; hexane T=-78 - 0°C; Addition;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
反应条件
1: (4S,5R)-1-benzyl-4-hydroxy-5-thiophenol-2-pyrrolidinone With n-butyllithium; naphthalenyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.5 h; 2: 4-methoxy-benzaldehyde in tetrahydrofuran; hexane T=-78 - 0°C; Addition;
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
反应条件
1: 23 percent / NaH / tetrahydrofuran / 0 °C 2: 34 percent / Bu4NF / tetrahydrofuran View Scheme
参考文献
Organic Letters, , vol. 2, # 24 p. 3949 - 3952
反应条件
1.1: 73 percent / p-toluenesylfonic acid monohydrate / CH2Cl2 / 52 h / 20 °C 2.1: n-BuLi, lithium naphthalenide / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 86.6 percent / tetrahydrofuran; hexane / -78 - 0 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 17 p. 3309 - 3317
