(S)-(-)-N-乙酰基-1-甲基苄胺合成路线 （共 50 条）
反应条件
hydrogen; (1R)-3-di-(3,5-dimethylphenyl)phosphino-(4-diphenylphosphino-2,5-dimethylthienyl-3)-1,7,7-trimethylbicyclo[2.2.1]heptene-2; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate in dichloromethane
T=20°C; P=6000.6 Torr; 16 h; Product distribution / selectivity;
参考文献
Degussa AG
Patent: EP1595888 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
triethylamine in tetrahydrofuran
T=20°C; 0.25 h;
参考文献
Nakamura, Tsuyoshi; Tateishi, Kaori; Tsukagoshi, Shiori; Hashimoto, Saori; Watanabe, Shotaro; Soloshonok, Vadim A.; Acena, Jose Luis; Kitagawa, Osamu
Tetrahedron, 2012 , vol. 68, # 21 p. 4013 - 4017
反应条件
1: (E)-acetophenone O-acetyl oxime With Rh(cod)2SbF6; CyPF-tBu; hydrogen in 1,4-dioxane
T=40°C; P=38002.6 Torr; 24 h; Autoclave;
2: acetic anhydride in 1,4-dioxane
0.5 h; Autoclave; SolventReagent/catalyst; Overall yield = 69 percentSpectr.; enantioselective reaction;
参考文献
Huang, Kexuan; Li, Shengkun; Chang, Mingxin; Zhang, Xumu
Organic Letters, 2013 , vol. 15, # 3 p. 484 - 487
反应条件
(Rp,S)-[2.2]paracyclophane-based N,O-ligand in hexane
T=0 - 20°C; 16 h; Title compound not separated from byproducts.;
参考文献
Dahment, Stefan; Braese, Stefan
Journal of the American Chemical Society, 2002 , vol. 124, # 21 p. 5940 - 5941
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
T=80°C; 3 h;
参考文献
Rodriguez, Veronica; Sanchez, Mario; Quintero, Leticia; Sartillo-Piscil, Fernando
Tetrahedron, 2004 , vol. 60, # 48 p. 10809 - 10815
反应条件
in dichloromethane
T=30°C; 12 h;
参考文献
Kita, Yasuyuki; Maeda, Hiroshi; Omori, Kana; Okuno, Takayuki; Tamura, Yasumitsu
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 23 p. 2999 - 3006
反应条件
didodecanoyl peroxide in 1,2-dichloro-ethane
4 h; Heating;
参考文献
Torres-Murro, Jaime; Quintero, Leticia; Sartillo-Piscil, Fernando
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7691 - 7694
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in n-heptane
T=35°C; Resolution of racemateMicrobiological reaction;
参考文献
Pilissao, Cristiane; De O. Carvalho, Patricia; Da G. Nascimento, Maria
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 6 p. 973 - 977
反应条件
Candida antarctica lipase B immobilized on acrylic resin in toluene
T=25°C; 0.666667 h; Resolution of racemateFlow reactor;
参考文献
De Miranda, Amanda S.; Miranda, Leandro S. M.; De Souza, Rodrigo O. M. A.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3332 - 3336
反应条件
Candida antarctica (Novozym 435)
T=21°C; 504 h; Enzymatic reaction;
参考文献
Davis; Durden
Synthetic Communications, 2001 , vol. 31, # 4 p. 569 - 578
