(S)-(-)-N-乙酰基-1-甲基苄胺合成路线 （共 50 条）
反应条件
1: triethylamine / tetrahydrofuran / 2 h / 20 °C
2: acetone / 4 h / 20 °C
3: 17 percent / dilauroyl peroxide / 1,2-dichloro-ethane / 4 h / Heating
View Scheme
参考文献
Torres-Murro, Jaime; Quintero, Leticia; Sartillo-Piscil, Fernando
Tetrahedron Letters, 2005 , vol. 46, # 45 p. 7691 - 7694
反应条件
2: aq. Na2CO3 / CH2Cl2 / 4 h / Ambient temperature
View Scheme
参考文献
Brown; Moudachirou
Tetrahedron, 1994 , vol. 50, # 34 p. 10309 - 10320
反应条件
in tetrahydrofuran; acetonitrile
T=-20°C; 40 h; Title compound not separated from byproducts;
参考文献
Maezaki, Naoyoshi; Furusawa, Akemi; Uchida, Shuji; Tanaka, Tetsuaki
Tetrahedron, 2001 , vol. 57, # 45 p. 9309 - 9315
反应条件
N,N'-dimethyl-N,N'-propyleneurea
T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Arseniyadis, Stellios; Valleix, Alain; Wagner, Alain; Mioskowski, Charles
Angewandte Chemie - International Edition, 2004 , vol. 43, # 25 p. 3314 - 3317
反应条件
1: ethanol
2: CF3SO3H-H2O (1:1; 10 equiv.) / Heating
3: NiCl2*6H2O; NaBH4
View Scheme
参考文献
Toshimitsu, Akio; Ito, Masaaki; Uemura, Sakae
Journal of the Chemical Society, Chemical Communications, 1989 , # 9 p. 530 - 531
反应条件
1: 1-amino-1-phenylethane With N,N'-dimethyl-N,N'-propyleneurea
T=-20°C; 24 h;
2: C10H14N2O5S2F6 With N,N'-dimethyl-N,N'-propyleneurea
T=-20°C; 24 h; Further stages.;
参考文献
Satyanarayana, Tummanapalli; Kagan, Henri B.
Tetrahedron, 2007 , vol. 63, # 28 p. 6415 - 6422
反应条件
pyridine; bis-(2-hydroxy-ethyl)-amine
1) MeOH, 1 h, reflux; Yield given. Multistep reaction;
参考文献
Knapp; Hale; Bastos; Molina; Chen
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6239 - 6256
参考文献
Pirkle, William H.; Welch, Christopher J.; Hyun, Myung Ho
Journal of Organic Chemistry, 1983 , vol. 48, p. 5022 - 5026
反应条件
in toluene
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Arseniyadis, Stellios; Valleix, Alain; Wagner, Alain; Mioskowski, Charles
Angewandte Chemie - International Edition, 2004 , vol. 43, # 25 p. 3314 - 3317
反应条件
N,N'-dimethyl-N,N'-propyleneurea
T=-20°C; 48 h;
参考文献
Satyanarayana, Tummanapalli; Kagan, Henri B.
Chemistry - A European Journal, 2006 , vol. 12, # 22 p. 5785 - 5789
