(S)-(-)-N-乙酰基-1-甲基苄胺合成路线 （共 50 条）
反应条件
1: glucose dehydrogenase; rabbit muscle L-lactate dehydrogenase; [3H]-L-Alanine; D-glucose; pyridoxal 5'-phosphate; nicotinamide adenine dinucleotide / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
2: 4-(N,N-dimethlyamino)pyridine
View Scheme
参考文献
Mutti, Francesco G.; Fuchs, Christine S.; Pressnitz, Desiree; Turrini, Nikolaus G.; Sattler, Johann H.; Lerchner, Alexandra; Skerra, Arne; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2012 , # 5 p. 1003 - 1007
反应条件
pyridine; potassium tert-butylate
1) ether, H2O, RT, 2) benzene, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kohmoto, Shigeo; Kreher, Thomas; Miyaji, Yoshiyuki; Yamamoto, Makoto; Yamada, Kazutoshi
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3490 - 3492
反应条件
in chloroform
T=23°C; 1 h;
参考文献
Miller, Shawn M.; Samame, Renzo A.; Rychnovsky, Scott D.
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20318 - 20321
反应条件
pyridine; potassium tert-butylate
1) ether, H2O, RT, 3 d, 2) benzene, 6 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kohmoto, Shigeo; Kreher, Thomas; Miyaji, Yoshiyuki; Yamamoto, Makoto; Yamada, Kazutoshi
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3490 - 3492
反应条件
pyridine; potassium tert-butylate
1) ether, H2O, RT, 3 d, 2) benzene, 6 h, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Kohmoto, Shigeo; Kreher, Thomas; Miyaji, Yoshiyuki; Yamamoto, Makoto; Yamada, Kazutoshi
Journal of Organic Chemistry, 1992 , vol. 57, # 12 p. 3490 - 3492
反应条件
in dichloromethane
T=-10°C; 10 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Al-Sehemi, Abdullah G.; Atkinson, Robert S.; Fawcett, John
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 257 - 274
反应条件
in chloroform-d1
T=-20 - 5°C; 14 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Al-Sehemi, Abdullah G.; Atkinson, Robert S.; Fawcett, John
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 2 p. 257 - 274
反应条件
in dichloromethane
T=-78°C; Acetylation; Product distribution; Further Variations:SolventsTemperatures;
参考文献
Ie, Yutaka; Fu, Gregory C.
Chemical Communications, 2000 , # 2 p. 119 - 120
反应条件
1: CF3SO3H-H2O (1:1; 10 equiv.) / Heating
2: NiCl2*6H2O; NaBH4
View Scheme
参考文献
Toshimitsu, Akio; Ito, Masaaki; Uemura, Sakae
Journal of the Chemical Society, Chemical Communications, 1989 , # 9 p. 530 - 531
反应条件
Cr(CO)3; sulfuric acid
Ambient temperature100percent retention of stereochemistry; Product distribution;
参考文献
Top, Siden; Jaouen, Gerard; McGlinchey, Michael J.
Journal of the Chemical Society, Chemical Communications, 1980 , # 23 p. 1110 - 1112
