3,4,5-三甲氧基苯甲酸甲酯合成路线 （共 184 条）
反应条件
1: 2M aq. NaOH / various solvent(s) / 0.25 h 2: thionyl chloride / 2 h / Heating View Scheme
参考文献
Takahashi, Rintaro; Nunokawa, Tatsuya; Shibuya, Tadahiro; Tomita, Ryohei; Tatewaki, Yoko; Okada, Shuji; Kimura, Tatsumi; Shimada, Satoru; Matsuda, Hiro
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 2 p. 236 - 244
反应条件
1: LiAlH4; diethyl ether 2: aqueous HCl View Scheme
参考文献
Schwachhofer,G.; Chopin,J.
Bulletin de la Societe Chimique de France, 1962 , p. 835 - 843
反应条件
1: acetic acid anhydride; nitrous acid; nitric acid 2: tin; hydrochloric acid View Scheme
参考文献
Zhang, Zhichao; Liang, Xiaomeng; Li, Xiangqian; Song, Ting; Chen, Qingbin; Sheng, Hongkun
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 711 - 718
反应条件
1: LiAlH4 / tetrahydrofuran 2: H2 / Pd-C / acetic acid / 2206.5 Torr / Ambient temperature 3: aq. H2O2, AcOH, H2SO4 View Scheme
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
反应条件
1: 86.4 percent / 99 percent N2H4*H2O / methanol / 5 h / Heating 2: 85 percent / K3Fe(CN)6; 25 percent NH4OH / H2O; CH2Cl2 / 4 h / 20 °C 3: 65 percent / Zn-Hg / acetic acid; toluene; H2O / 0.75 h / Heating 4: 80 percent / 50 percent H2O2; 98 percent HCOOH; phosphomolybdic acid / 0.25 h / 20 °C View Scheme
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
参考文献
Clemence; Joliveau-Maushart; Meier; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 257 - 266
反应条件
in methanol T=20°C; Reflux;
参考文献
Borchhardt, Deise M.; Mascarello, Alessandra; Chiaradia, Louise Domeneghini; Nunes, Ricardo J.; Oliva, Glaucius; Yunes, Rosendo A.; Andricopulo, Adriano D.
Journal of the Brazilian Chemical Society, 2010 , vol. 21, # 1 p. 142 - 150
反应条件
1: lithium aluminium hydride / diethyl ether / 3 h / Heating 2: pyridinium chlorochromate / CH2Cl2 / 3 h 3: sodium acetate / acetic anhydride / Heating 4: NaOH / H2O / Heating 5: hydroxylamine hydrochloride / aq. NaOH / 0.5 h / 60 °C 6: acetic anhydride / 0.08 h / Heating 7: ZnCl2, HCl / diethyl ether / 5 h / 0 °C 8: 2.0 g / aq. potassium persulphate / aq. KOH / Ambient temperature 9: K2CO3 / acetone / 50 h / Heating 10: 1) Na, 2) conc.hydrochloric acid / 1) r.t., 2) heating, 15-20 min. View Scheme
参考文献
Shaw; Srivastava; Jha
Journal of the Indian Chemical Society, 1990 , vol. 67, # 2 p. 144 - 147
反应条件
1: 70 percent / LAH / tetrahydrofuran 2: 80 percent / PBr3, triethylamine / CCl4 / 1) 1h, 0 degC 2) 3h, roomtemp. 3: 75 percent / dimethylsulfoxide / Ambient temperature 4: 92 percent / 3N KOH / Heating View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
sodium methylate; 1,2-dichloro-benzene T=80°C;
参考文献
Gu, Xiaoke; Ren, Zhiguang; Tang, Xiaobo; Peng, Hui; Ma, Yuanfang; Lai, Yisheng; Peng, Sixun; Zhang, Yihua
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 8 p. 2540 - 2548
