3,4,5-三甲氧基苯甲酸甲酯合成路线 （共 184 条）
反应条件
hydroxylamine hydrochloride; potassium hydroxide in methanol 24 h; Reflux;
参考文献
Kreye, Oliver; Wald, Sarah; Meier, Michael A. R.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 81 - 86
反应条件
1: nitric acid / acetic acid / 1 h / 20 °C / |Cooling with ice 2: SnCl2·2H2O; hydrogenchloride / ethanol / |Inert atmosphere; |Reflux 3: sodium hydroxide; water / ethanol / 45 - 50 °C 4: 5 h / 130 - 140 °C View Scheme
参考文献
Zhang, Zhichao; Liang, Xiaomeng; Li, Xiangqian; Song, Ting; Chen, Qingbin; Sheng, Hongkun
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 711 - 718
反应条件
1: Cu(NO3)2, Ac2O 2: (alkaline hydrolysis) 3: NaBH4, BF3-Et2O 4: NaH 5: LiBr View Scheme
参考文献
Williams,K.I.H. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 3982 - 3988
反应条件
alkaline earth in waessr. oder alkoh. Loesung unter Druck;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 2 h;
参考文献
Yang, Chang-An; Wang, Guo; Xie, He Lou; Zhang, Hai Liang
Polymer, 2010 , vol. 51, # 20 p. 4503 - 4510
反应条件
1: 72 percent / LiAlH4 / tetrahydrofuran / Heating 2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C 3: 92 percent / NaH; PhSH; HMPT / toluene / Heating View Scheme
参考文献
Zou, Hong Bin; Dong, Sheng Yi; Zhou, Chang Xin; Hu, Li Hong; Wu, Yi Hang; Li, Hai Bo; Gong, Jing Xu; Sun, Lian Li; Wu, Xiu Mei; Bai, Hua; Fan, Bo Tao; Hao, Xiao Jiang; Stoeckigt, Joachim; Zhao, Yu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2060 - 2071
反应条件
1: 70 percent / LAH / tetrahydrofuran 2: 80 percent / PBr3, triethylamine / CCl4 / 1) 1h, 0 degC 2) 3h, roomtemp. 3: 75 percent / dimethylsulfoxide / Ambient temperature View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 3 p. 173 - 175
反应条件
magnesium in tetrahydrofuran T=20°C; Grignard reaction; 1.33333 h; Reflux;
参考文献
Saxena, Hari Om; Faridi, Uzma; Srivastava, Suchita; Kumar; Darokar; Luqman, Suaib; Chanotiya; Krishna, Vinay; Negi, Arvind S.; Khanuja
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 3914 - 3918
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
反应条件
1: 72 percent / LiAlH4 / tetrahydrofuran / Heating 2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C 3: 30 percent / AlCl3 / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Zou, Hong Bin; Dong, Sheng Yi; Zhou, Chang Xin; Hu, Li Hong; Wu, Yi Hang; Li, Hai Bo; Gong, Jing Xu; Sun, Lian Li; Wu, Xiu Mei; Bai, Hua; Fan, Bo Tao; Hao, Xiao Jiang; Stoeckigt, Joachim; Zhao, Yu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2060 - 2071
