3,4,5-三甲氧基苯甲酸甲酯合成路线 （共 184 条）
反应条件
1: 1.74 g / LiOH / methanol; H2O / 2 h / 20 °C 2: 96 percent / 1,3-dibromo-5,5-dimethylhydantoin; aq. NaOH / 36 h / 20 °C View Scheme
参考文献
Hamburg
Monatshefte fuer Chemie, 1898 , vol. 19, p. 594
反应条件
1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 24 h / |Reflux 2: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-diaza-bicyclo[2.2.2]octane; triethylamine / methanol / 3 h / |Reflux; |Green chemistry View Scheme
参考文献
Kreye, Oliver; Wald, Sarah; Meier, Michael A. R.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 81 - 86
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
反应条件
bromine in chloroform
参考文献
Insole, Joan M.
Journal of Chemical Research, Miniprint, 1990 , # 12 p. 2831 - 2867
反应条件
acetic anhydride; iron(III) chloride
参考文献
Horning; Parker
Journal of the American Chemical Society, 1952 , vol. 74, p. 2107
参考文献
Hamburg
Monatshefte fuer Chemie, 1898 , vol. 19, p. 594
反应条件
1: HNO3 / acetic anhydride / -5 - 0 °C
2: H2 / Raney-Ni / acetic acid
3: N2H4*H2O / propan-2-ol / Heating
4: Raney-Ni / propan-2-ol / Heating
View Scheme
参考文献
Dallacker,F. et al.
Monatshefte fuer Chemie, 1960 , vol. 91, p. 1077 - 1088
反应条件
1: methanol; hydrazine hydrate
2: pyridine
View Scheme
参考文献
Buchanan; Cook; Loudon
Journal of the Chemical Society, 1944 , p. 325,327
反应条件
1: 72 percent / LiAlH4 / tetrahydrofuran / Heating
2: 85 percent / pyridinium chlorochromate / CH2Cl2 / 20 °C
3: 30 percent / AlCl3 / CH2Cl2 / 12 h / 20 °C
4: 75 percent / triethylamine / 2 h / 20 °C
View Scheme
参考文献
Zou, Hong Bin; Dong, Sheng Yi; Zhou, Chang Xin; Hu, Li Hong; Wu, Yi Hang; Li, Hai Bo; Gong, Jing Xu; Sun, Lian Li; Wu, Xiu Mei; Bai, Hua; Fan, Bo Tao; Hao, Xiao Jiang; Stoeckigt, Joachim; Zhao, Yu
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2060 - 2071
反应条件
N,N,N',N,-tetramethylethylenediamine; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; Addition;
参考文献
Douglas, Christopher J.; Sklenicka, Heather M.; Shen, Hong C.; Mathias, David S.; Degen, Shane J.; Golding, Geoffrey M.; Morgan, Christopher D.; Shih, Regina A.; Mueller, Kristen L.; Seurer, Lisa M.; Johnson, Erik W.; Hsung, Richard P.
Tetrahedron, 1999 , vol. 55, # 48 p. 13683 - 13696
