3,4,5-三甲氧基苯甲酸甲酯合成路线 （共 184 条）
反应条件
acetic anhydride; iron(III) chloride
Erwaermen der Reaktionsloesung bis auf 100grad;
参考文献
Horning; Parker
Journal of the American Chemical Society, 1952 , vol. 74, p. 2107
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Friedrich; Mirbach
Chemische Berichte, 1959 , vol. 92, p. 2574,2575, 2577
反应条件
tetrachloromethane; bromine
anschliessendes Erwaermen der mit wenig Eisen-Pulver versetzten Reaktionsloesung;
参考文献
Friedrich; Mirbach
Chemische Berichte, 1959 , vol. 92, p. 2574,2575, 2577
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran
2: thionyl chloride / dichloromethane
3: potassium carbonate / dimethyl sulfoxide / 6 h / 50 °C
View Scheme
参考文献
Zheng, Cheng; Guo, Yibing; Meng, Ying; Dou, Sufeng; Shao, Jian; Yang, Yumin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 5 p. 654 - 664
反应条件
1: 1.) LAH, 2.) PDC / 1.) THF, 2.) CH2Cl2
2: NH3 / methanol / 5 h / 45 °C
3: 1.) HCl gas, 2.) SOCl2 / 1.) room temperature, 12 h, 2.) 55 deg C, 3 h
4: Et3N / CH2Cl2 / 2 h / Ambient temperature
5: 6N HCl / Heating
View Scheme
参考文献
Bois-Choussy; Zhu
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5662 - 5665
反应条件
1: hydrazine hydrate
2: alcohol
View Scheme
参考文献
Kalb; Gross
Chemische Berichte, 1926 , vol. 59, p. 733
反应条件
iodine; sodium carbonate
参考文献
Trivedi, K. K.; Kochak, Geeta; Misra, K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 9 p. 925 - 926
反应条件
2: acetic acid; ozone / 60 °C
View Scheme
参考文献
Bogert; Isham
Journal of the American Chemical Society, 1914 , vol. 36, p. 518
反应条件
1: LiAlH4, AlBr3
2: aq. HCl
3: N2H4*H2O
View Scheme
参考文献
Kost,A.N. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 6 p. 2011 - 2015,1957 - 1960
反应条件
1: lithium borohydride / methanol / 20 °C
2: phosphorus tribromide / benzene / 20 °C
3: toluene / 120 °C
View Scheme
参考文献
Parihar, Swati; Kumar, Amit; Chaturvedi, Amit K.; Sachan, Naresh Kumar; Luqman, Suaib; Changkija, Bendangla; Manohar, Murli; Prakash, Om; Chanda; Khan, Feroz; Chanotiya; Shanker, Karuna; Dwivedi, Anila; Konwar, Rituraj; Negi, Arvind S.
Journal of Steroid Biochemistry and Molecular Biology, 2013 , vol. 137, p. 332 - 344
参考文献
Warner-Lambert Company
Patent: US4056619 A1, 1977 ;
