(s)-4-(cbz-氨基)-5-甲基-3-氧代己酸叔丁酯合成路线 （共 4 条）
反应条件
1: acetic acid tert-butyl ester With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-50°C; 2: methyl (2S)-3-methyl-[(benzyloxy)carbonylamino]butanoate in tetrahydrofuran; n-heptane; ethylbenzene T=-55°C; cross-Claisen condensation;
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Izawa, Kunisuke
Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3163 - 3166
反应条件
1: N-(carbobenzyloxy)-L-valine; 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 1 h; 2: acetic acid tert-butyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h;
参考文献
Shie, Jiun-Jie; Fang, Jim-Min; Kuo, Tun-Hsun; Kuo, Chih-Jung; Liang, Po-Huang; Huang, Hung-Jyun; Wu, Yin-Ta; Jan, Jia-Tsrong; Cheng, Yih-Shyun E.; Wong, Chi-Huey
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 17 p. 5240 - 5252
反应条件
1: N-(carbobenzyloxy)-L-valine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; Inert atmosphere; 2: acetic acid tert-butyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 3 h; Inert atmosphere;
参考文献
Lin, Daizong; Qian, Wangke; Hilgenfeld, Rolf; Jiang, Hualiang; Chen, Kaixian; Liu, Hong
Science China Chemistry, 2012 , vol. 55, # 6 p. 1101 - 1107
反应条件
1,1'-carbonyldiimidazole 1.) THF, room temperature, 1 h, 2.) -78 deg C, 40 min; Yield given. Multistep reaction;
参考文献
Hoffman, Robert V.; Tao, Junhua
Tetrahedron, 1997 , vol. 53, # 21 p. 7119 - 7126
