三乙二醇二(对甲苯磺酸酯)合成路线 （共 90 条）
反应条件
1: (i) NaH, THF, (ii) /BRN= 632509/
2: LiAlH4 / tetrahydrofuran / Heating
3: aq. HCHO
View Scheme
参考文献
Johnson,M.R. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 357 - 371
反应条件
sodium hydride in tetrahydrofuran
参考文献
Schultz, Rose Ann; Dishong, Dennis M.; Gokel, George W.
Tetrahedron Letters, 1981 , vol. 22, # 28 p. 2623 - 2626
反应条件
tetrabutylammomium bromide; sodium hydroxide in water; benzene
T=70°C; 10 h; Reagent/catalyst;
参考文献
Luk'yanenko; Basok; Kulygina, E. Yu.; Bogashchenko, T. Yu.; Yakovenko
Russian Journal of Organic Chemistry, 2012 , vol. 48, # 10 p. 1345 - 1352
Zh. Org. Khim., 2012 , vol. 48, # 10 p. 1350 - 1357,8
反应条件
1: (i) NaH, THF, (ii) /BRN= 632509/
2: LiAlH4 / tetrahydrofuran / Heating
3: K2CO3 / acetonitrile
View Scheme
参考文献
Johnson,M.R. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 357 - 371
反应条件
sodium hydride in tetrahydrofuran
T=25°C;
参考文献
Gibson, Harry W.; Bheda, Mukesh C.; Engen, Paul; Shen, Ya Xi; Sze, Jean; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 8 p. 2186 - 2196
反应条件
potassium carbonate in benzene
73 h; Heating;
参考文献
Kimura, Masaru; Kajita, Kazushige; Onoda, Naoyuki; Morosawa, Shiro
Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4887 - 4892
反应条件
sodium hydride in N,N-dimethyl-formamide
T=100°C; 16 h;
参考文献
Ball; Cooper; Main
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 2 p. 137 - 143
反应条件
1: sodium / ethanol / 20 °C / Heating
2: KOH / aq. methanol / 6 h / Heating
View Scheme
参考文献
Suzuki, Yoshio; Morozumi, Tatsuya; Nakamura, Hiroshi; Shimomura, Masatsugu; Hayashita, Takashi; Bartsh, Richard A.
Journal of Physical Chemistry B, 1998 , vol. 102, # 40 p. 7910 - 7917
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
