2-(5-溴吡啶-2-基)乙酸合成路线 （共 7 条）
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 3 h; 2: With hydrogenchloride in water pH=3 - 4;
参考文献
Liang, Chungen; Tang, Guozhi; Wong, Jason Christopher; Wu, Xihan
Patent: US2010/69328 A1, 2010 ;
Location in patent: Page/Page column 36 ;
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Jones, Gurnos; Pitman, Mark A.; Lunt, Edward; Lythgoe, David J.; Abarca, Belen; Ballesteros, Rafael; Elmasnaouy, Mostafa
Tetrahedron, 1997 , vol. 53, # 24 p. 8257 - 8268
反应条件
1: 25 percent / Ac2O / 5 - 20 °C 2: 83 percent / conc. HCl / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 53, # 24 p. 8257 - 8268
反应条件
1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 0 - 25 °C 2: acetic anhydride / 0 - 25 °C 3: hydrogenchloride / water / 2 h / Reflux View Scheme
参考文献
WO2011/45703 A2, ;
WO 2011/045703 A2
反应条件
1: caesium carbonate; copper(l) iodide; pyridine-2-carboxylic acid / 1,4-dioxane / 16 h / 80 °C 2: water; lithium hydroxide hydrate / tetrahydrofuran / 3 h / 60 °C View Scheme
反应条件
1: With borane-THF in tetrahydrofuran T=20°C; 19 h; Inert atmosphere; 2: With acetic acid in tetrahydrofuran; water
参考文献
Nippon Chemiphar Co., Ltd.
Patent: EP2311822 A1, 2011 ;
Location in patent: Page/Page column 51 ;
反应条件
thionyl chloride
T=0 - 20°C; 3 h;
参考文献
Liang, Chungen; Tang, Guozhi; Wong, Jason Christopher; Wu, Xihan
Patent: US2010/69328 A1, 2010 ;
Location in patent: Page/Page column 36 ;
