2,3,4,9-四氢-8-甲基-1H-咔唑合成路线 （共 17 条）
反应条件
liquid 1-butyl-3-methylimidazolium hydrosulfate
T=70°C; Fischer indole synthesis; 0.5 h;
参考文献
Xu, Dan-Qian; Yang, Wen-Long; Luo, Shu-Ping; Wang, Bing-Tao; Wu, Jian; Xu, Zhen-Yuan
European Journal of Organic Chemistry, 2007 , # 6 p. 1007 - 1012
反应条件
ammonium cerium (IV) nitrate in methanol
Fischer indole synthesis; 1 h; Reflux;
参考文献
Varma, P. Prabhakara; Sherigara, Bailure S.; Mahadevan, Kittapa M.; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 1 p. 158 - 165
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tri-ruthenium(0)dodecacarbonyl; toluene-4-sulfonic acid in 1,4-dioxane
T=150°C; 22 h; Inert atmosphere;
参考文献
Pena-Lopez, Miguel; Neumann, Helfried; Beller, Matthias
Chemistry - A European Journal, 2014 , vol. 20, # 7 p. 1818 - 1824
反应条件
tris(triphenylphosphine)ruthenium(II) chloride in 1,4-dioxane
T=180°C; 50 h;
参考文献
Tsuji, Yasushi; Huh, Keun-Tae; Watanabe, Yoshihisa
Journal of Organic Chemistry, 1987 , vol. 52, # 9 p. 1673 - 1680
反应条件
1: cyclohexenyl bromide With magnesium
Metallation;
2: 2-methylnitrobenzene in tetrahydrofuran
T=-45 - -40°C; Cyclization; Bartoli reaction;
参考文献
Dobbs, Adrian P.; Voyle, Martyn; Whittall, Neil
Synlett, 1999 , # 10 p. 1594 - 1596
反应条件
in ethanol
10 h; Heating;
参考文献
Kuroki, Masanate; Tsunashima, Yutaka
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 709 - 714
反应条件
1: benzene / Heating
2: 60 percent / NaNH2-t-BuONa / 2-methyl-propan-2-ol; tetrahydrofuran / 576 h / 50 °C
View Scheme
参考文献
Caubere, Catherine; Caubere, Paul; Ianelli, Sandra; Nardelli, Mario; Jamart-Gregoire, Brigitte
Tetrahedron, 1994 , vol. 50, # 41 p. 11903 - 11920
反应条件
1: benzene / Heating
2: 60 percent / NaNH2-t-BuONa / 2-methyl-propan-2-ol; tetrahydrofuran / 576 h / 50 °C
View Scheme
参考文献
Caubere, Catherine; Caubere, Paul; Ianelli, Sandra; Nardelli, Mario; Jamart-Gregoire, Brigitte
Tetrahedron, 1994 , vol. 50, # 41 p. 11903 - 11920
反应条件
hydrogenchloride
T=150°C;
参考文献
Jones; Tomlinson
Journal of the Chemical Society, 1953 , p. 4114
反应条件
T=150°C; Addition; 5 h;
参考文献
Mustafin; Khalilov; Ismagilov; Baimetov; Spirikhin; Abdrakhmanov; Tolstikov
Russian Chemical Bulletin, 1999 , vol. 48, # 11 p. 2121 - 2126
