1-甲基-3,5-二苯基-吡唑合成路线 （共 73 条）
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
Suzuki-Miyaura coupling; 18 h; Reflux;
参考文献
Beltran-Rodil, Sandra; Edwards, Michael G.; Pugh, David S.; Reid, Mark; Taylor, Richard J.K.
Synlett, 2010 , # 4 art. no. D27509ST, p. 602 - 606
反应条件
1: 71 percent / piperidine / ethanol / 40 h
2: 51 percent / NaOEt / ethanol / Heating
3: 90 percent / NaOEt / ethanol / Heating
View Scheme
参考文献
Katritzky; Wang; Zhang; Voronkov; Steel
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6787 - 6791
反应条件
1: 51 percent / NaOEt / ethanol / Heating
2: 90 percent / NaOEt / ethanol / Heating
View Scheme
参考文献
Katritzky; Wang; Zhang; Voronkov; Steel
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6787 - 6791
参考文献
BASF Aktiengesellschaft
Patent: US5840913 A1, 1998 ;
反应条件
1: 2-(di-1-adamantylphosphanyl)-1-(2,6-diisopropylphenyl)-1H-imidazole; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; triethylamine / 1,4-dioxane / 20 h / 100 °C / 3750.38 Torr / Inert atmosphere; Autoclave
2: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
European Journal of Organic Chemistry, 2011 , # 25 p. 4919 - 4924
反应条件
in ethanol
4 h; Ambient temperature;
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
1: [Pd(η3-1-Ph-allyl)(μ-Cl)]2; triethylamine; N-(naphthyl)-2-(dicyclohexylphosphino)-pyrrole / N,N-dimethyl-formamide / 20 h / 120 °C / 7500.75 Torr / Inert atmosphere; Autoclave
2: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
European Journal of Organic Chemistry, 2011 , # 25 p. 4919 - 4924
反应条件
1: 2-(di-1-adamantylphosphanyl)-1-(2,6-diisopropylphenyl)-1H-imidazole; [Pd(η3-1-Ph-allyl)(μ-Cl)]2; triethylamine / 1,4-dioxane / 20 h / 100 °C / 3750.38 Torr / Inert atmosphere; Autoclave
2: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
European Journal of Organic Chemistry, 2011 , # 25 p. 4919 - 4924
反应条件
1: 1,4-dioxane / 1 h / 20 °C / Inert atmosphere
2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Wu, Xiao-Feng; Neumann, Helfried; Beller, Matthias
European Journal of Organic Chemistry, 2011 , # 25 p. 4919 - 4924
反应条件
1: 5 wt Cu/Fe / N,N-dimethyl-formamide / 3 h / 100 °C
2: N,N-dimethyl-formamide / 5 h / 100 °C
View Scheme
参考文献
Kovacs, Szabolcs; Novak, Zoltan
Tetrahedron, 2013 , vol. 69, # 43 p. 8987 - 8993
