顺式-11-十八烯酸甲酯合成路线 （共 28 条）
反应条件
1: 11-(1-phenyl-1H-tetrazole-5-sulfonyl)undecanoic acid methyl ester With potassium hexamethylsilazane in tetrahydrofuran; toluene T=-55°C; 0.666667 h; 2: heptanal in tetrahydrofuran; toluene T=-55°C; Julia-Kocienski olefination; 1 h;
参考文献
Duffy, Patricia E.; Quinn, Sonia M.; Roche, Helen M.; Evans, Paul
Tetrahedron, 2006 , vol. 62, # 20 p. 4838 - 4843
反应条件
hydrogen; ethylenediamine in ethanol; water stereoselective reaction;
参考文献
Fu, Yu; Weng, Yue; Hong, Wen-Xu; Zhang, Qinghai
Synlett, 2011 , # 6 p. 809 - 812
反应条件
1.1: 80 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C 2.1: m-CPBA / CH2Cl2 / 48 h / 0 - 20 °C 3.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.67 h / -55 °C 3.2: tetrahydrofuran; toluene / 1 h / -55 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 20 p. 4838 - 4843
反应条件
1.1: m-CPBA / CH2Cl2 / 48 h / 0 - 20 °C 2.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.67 h / -55 °C 2.2: tetrahydrofuran; toluene / 1 h / -55 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 20 p. 4838 - 4843
反应条件
1.1: 61 percent / H2SO4 / 12 h / Heating 2.1: 80 percent / NaH / dimethylformamide / 12 h / 0 - 20 °C 3.1: m-CPBA / CH2Cl2 / 48 h / 0 - 20 °C 4.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.67 h / -55 °C 4.2: tetrahydrofuran; toluene / 1 h / -55 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 20 p. 4838 - 4843
反应条件
1: 1.) tetrapropyldiborane, 2.) aq. NaOH, aq. H2O2 / 1) THF, 0 deg C, 30 min, 0 --> 20 deg C, 2 h; 2) THF, MeOH, - 5 deg C; further reagents: dimethyl sulfate, NaBH4 2: 55 percent / pyridinium chlorochromate, CH3COONa / CH2Cl2 3: 1.) (Me3Si)2NNa / 1) THF, room temperature, 30 min, reflux, 1 h; 2) -78 --> 20 deg C, overnight (room temperature) View Scheme
参考文献
Russian Chemical Bulletin, , vol. 43, # 6 p. 1079 - 1080
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 6 p. 1141 - 1142
反应条件
1: 55 percent / pyridinium chlorochromate, CH3COONa / CH2Cl2 2: 1.) (Me3Si)2NNa / 1) THF, room temperature, 30 min, reflux, 1 h; 2) -78 --> 20 deg C, overnight (room temperature) View Scheme
参考文献
Russian Chemical Bulletin, , vol. 43, # 6 p. 1079 - 1080
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 6 p. 1141 - 1142
反应条件
1: (i) NaOEt, (ii) /BRN= 1560236/, (iii) aq. NaOH View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 32, # 6 p. 1802 - 1807,1785 - 1789
反应条件
1: (i) NaOEt, (ii) /BRN= 1560236/, (iii) aq. NaOH View Scheme
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 32, # 6 p. 1802 - 1807,1785 - 1789
反应条件
2-hydroxyethanethiol; Nitrous oxide; tert-butyl alcohol T=22°C; γ-Irradiation; Product distributionEquilibrium constantKinetics; Further Variations:absorbed dose of radiation;
参考文献
Journal of the American Chemical Society, , vol. 124, # 43 p. 12816 - 12823
