1-硝基-4-苯基乙炔苯合成路线 （共 107 条）
反应条件
1: 80 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature
2: 8 percent / t-BuOK, air / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Akiyama, Shuzo; Tajima, Kunihiko; Nakatsuji, Shin'ichi; Nakashima, Kenichiro; Abiru, Kazuko; Watanabe, Miwa
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2043 - 2052
反应条件
1: 80 percent / NaOEt / ethanol; dimethylformamide / 3 h / Ambient temperature
2: 8 percent / t-BuOK, air / dimethylformamide / 1.5 h / Ambient temperature
View Scheme
参考文献
Akiyama, Shuzo; Tajima, Kunihiko; Nakatsuji, Shin'ichi; Nakashima, Kenichiro; Abiru, Kazuko; Watanabe, Miwa
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 7 p. 2043 - 2052
反应条件
silica-supported palladium catalyst
T=70°C; Sonogashira coupling; 1 h;
参考文献
Tyrrell, Elizabeth; Whiteman, Leon; Williams, Neil
Synthesis, 2009 , # 5 p. 829 - 835
反应条件
sodium methylate in methanol
参考文献
Youssef,A.-H.A.; Abdel-Rehiem,A.G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 101 - 105
反应条件
1: 83 percent / N2O4 / tetrahydrofuran / 2 h
2: 90 percent / 210 °C / 5 Torr
View Scheme
参考文献
Bestmann, Hans Juergen; Kamberger, Werner; Roeder, Thomas; Zimmermann, Reiner
Liebigs Annales, 1996 , # 5 p. 845 - 851
反应条件
1: CuCl2*2H2O / aq. HCl
2: KOH / dioxane
View Scheme
参考文献
Dombrovskii,A.V.; Taschchuk,K.G.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 1 p. 165 - 170,158 - 162
反应条件
1: CuCl2*2H2O / aq. HCl
2: KOH / dioxane
View Scheme
参考文献
Dombrovskii,A.V.; Taschchuk,K.G.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 1 p. 165 - 170,158 - 162
反应条件
1: PCl5 / 1 h
2: NaOMe / methanol
View Scheme
参考文献
Youssef,A.-H.A.; Abdel-Rehiem,A.G.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 101 - 105
反应条件
1: Br2
2: KOH / methanol
View Scheme
参考文献
Veschambre,H. et al.
Bulletin de la Societe Chimique de France, 1967 , p. 134 - 139
反应条件
1: triphenylphosphine / dichloromethane / 0 °C
2: copper(l) iodide; 8-hydroxy-quinoline; potassium phosphate / ethanol / 12 h / 100 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Liu, Jidan; Dai, Fenglin; Yang, Zhiyong; Wang, Sizhuo; Xie, Kai; Wang, Anwei; Chen, Xiang; Tan, Ze
Tetrahedron Letters, 2012 , vol. 53, # 42 p. 5678 - 5683
