7-氟-2-甲基-4-羟基喹唑啉合成路线 （共 4 条）
反应条件
1: 2-amino-4-fluoro-benzoic acid; acetic anhydride in hepatene 3 h; Heating / reflux; 2: ammonium acetate in n-heptane 3: acetic acid 16 h; Heating / reflux;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2006/51290 A2, 2006 ;
Location in patent: Page/Page column 132-133 ;
WO 2006/051290 A2
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / 20 °C 2: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
反应条件
1: triethylamine; ammonia / tetrahydrofuran; water / 2.5 h 2: toluene-4-sulfonic acid / tetrahydrofuran / 0.17 h / 20 °C 3: [bis(acetoxy)iodo]benzene / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Synthesis (Germany), , vol. 45, # 21 art. no. SS-2013-H0422-OP, p. 2998 - 3006
参考文献
Shen, Zhenlu; Hong, Yiming; He, Xiaofei; Mo, Weimin; Hu, Baoxiang; Sun, Nan; Hu, Xinquan
Organic Letters, 2010 , vol. 12, # 3 p. 552 - 555
