1-[[(4-硝基苯氧基)羰基]氧基]-2-甲基丙酸乙酯合成路线 （共 5 条）
反应条件
1: 2-methyl propanoic acid With zinc oxide in toluene T=105°C; 1 h; 2: (1-chloroethyl)-(4-nitrophenyl)carbonate With sodium iodide in toluene T=60°C; 24 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; BEN-MOHA-LERMAN, Elena; NIDAM, Tamar; COHEN, Meital; AVHAR-MAYDAN, Sharon; BALANOV, Anna
Patent: WO2010/63002 A2, 2010 ;
Location in patent: Page/Page column 27-28 ;
反应条件
acetic acid Heating;
参考文献
Lin, Yang-I.; Bitha, Panayota; Li, Zhong; Sakya, Subas M.; Strohmeyer, Timothy W.; Lang Jr., Stanley A.; Yang, Youjun; Bhachech, Niraja; Weiss, William J.; Petersen, Peter J.; Jacobus, Nilda V.; Bush, Karen; Testa, Raymond T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1811 - 1816
反应条件
1: 4-nitro-phenol; 1-chloroethyl chlorocarbonate With tributyl-amine in toluene T=20°C; 2: 2-methyl propanoic acid With zinc oxide; sodium iodide in toluene T=75°C; 10 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; BEN-MOHA-LERMAN, Elena; NIDAM, Tamar; COHEN, Meital; AVHAR-MAYDAN, Sharon; BALANOV, Anna
Patent: WO2010/63002 A2, 2010 ;
Location in patent: Page/Page column 26-27 ;
反应条件
1: 90 percent / TEA / Ambient temperature 2: 85 percent / MeCO2H / Heating View Scheme
参考文献
Lin, Yang-I.; Bitha, Panayota; Li, Zhong; Sakya, Subas M.; Strohmeyer, Timothy W.; Lang Jr., Stanley A.; Yang, Youjun; Bhachech, Niraja; Weiss, William J.; Petersen, Peter J.; Jacobus, Nilda V.; Bush, Karen; Testa, Raymond T.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1811 - 1816
反应条件
chloro-trimethyl-silane; tributyl-amine in toluene T=20°C; 24 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; BEN-MOHA-LERMAN, Elena; NIDAM, Tamar; COHEN, Meital; AVHAR-MAYDAN, Sharon; BALANOV, Anna
Patent: WO2010/63002 A2, 2010 ;
Location in patent: Page/Page column 28 ;
