1.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 1.2: 2 h / 20 °C 2.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 3.1: hydrogenchloride; water / 3 h / 100 °C 4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 5.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 6.1: hydrogen bromide / water / 2 h / Reflux View Scheme

1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 2: hydrogenchloride; water / 3 h / 100 °C 3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 4: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 5: hydrogen bromide / water / 2 h / Reflux View Scheme

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere 1.2: 0.5 h / Inert atmosphere 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C 3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 3.2: 4 h / 70 °C / Inert atmosphere 4.1: hydrogenchloride; water / methanol / 2 h / 20 °C 5.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 6.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 6.2: 2 h / 20 °C 7.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 8.1: hydrogenchloride; water / 3 h / 100 °C 9.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 10.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 11.1: hydrogen bromide / water / 2 h / Reflux View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 2: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 3: hydrogen bromide / water / 2 h / Reflux View Scheme

1: hydrogenchloride; water / 3 h / 100 °C 2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 3: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 4: hydrogen bromide / water / 2 h / Reflux View Scheme

lead(IV) acetate 0.25 h; Ambient temperature;

lead(IV) acetate; trifluoroacetic acid 0.25 h; Ambient temperature;

sulfuric acid; water; sodium nitrite 1.) 0-5 deg C, 15 min, 2.) reflux, 1 h; Yield given. Multistep reaction;

phosphate buffer; Escherichia coli β-glucuronidase T=37°C; pH=7.0; Enzyme kinetics;

1: 83 percent / HNO3; AcOH / ethyl acetate / 1 h 2: Et3N; DMAP / CH2Cl2 3: 74 percent / HCO2H; Et3N; DPPF / Pd(AcO)2 / dioxane / 70 °C View Scheme