sulfuric acid; iodine; potassium iodide; sodium nitrite in water; dimethyl sulfoxide T=0 - 80°C; 6.25 h;

1: With sodium hydroxide; mercury(II) diacetate 2: With iodine; potassium iodide Further stages.;

iodine in dichloromethane 24 h; Ambient temperature; Further byproducts given;

mercury(II) diacetate; iodine; potassium iodide 1.) H2O, 100 deg C, 0.5 h, 2.) H2O, RT, 3 h; Yield given. Multistep reaction. Yields of byproduct given;

暂无反应条件数据

暂无反应条件数据

1.1: 97 percent / K2CO3 / dimethylformamide / 20 °C 2.1: 60 percent / Fe; AcOH / ethanol / 3.5 h / Heating 3.1: NaHCO3; HCO2Na; n-Bu4NCl / Pd(OAc)2; NaCl / 1 h 3.2: 58 percent / Ac2O / 12 h / Heating View Scheme

1: triethylamine / dichloromethane / 0 - 20 °C / |Inert atmosphere 2: palladium diacetate; sodium carbonate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine / N,N-dimethyl-formamide; water / 100 °C 3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 3 h / 0 - 20 °C 4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C / |Inert atmosphere 5: water; hydrogenchloride / dichloromethane; methanol / 0 - 20 °C 6: triethylamine / dichloromethane / |Inert atmosphere; |Reflux 7: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; ethanol; toluene / 100 °C 8: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 3 h / 0 - 20 °C 9: pyridine / chloroform / |Inert atmosphere; |Reflux 10: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / |Inert atmosphere; |Reflux 11: tris-(dibenzylideneacetone)dipalladium(0); (S)-i-Pr-PHOX / dichloromethane / 20 °C / |Inert atmosphere 12: Grubb's 2nd generation catalyst / 40 °C / |Inert atmosphere 13: triethyl phosphite / 170 °C / |Inert atmosphere 14: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / |Reflux 15: copper; quinoline / 3 h / 190 °C / |Inert atmosphere 16: sodium; naphthalene / ethylene glycol dimethyl ether / 0.25 h / -78 °C / |Inert atmosphere View Scheme

potassium carbonate in N,N-dimethyl-formamide T=20°C;

sodium hydroxide