3-(4-甲氧基苯基)哌啶合成路线 （共 11 条）
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in methanol P=2585.7 Torr;
参考文献
Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.) 0.5 h, room temp., 2.) 4 h, reflux;
参考文献
Kanao; Hashizume; Ichikawa; Irie; Satoh; Isoda
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 1 p. 180 - 188
反应条件
1: 32 percent / dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature 2: H2, conc. HCl / PtO2 / methanol / 2585.7 Torr View Scheme
参考文献
Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
反应条件
1: 32 percent / dichlorobis(triphenylphosphine)nickel(II) / tetrahydrofuran / 24 h / Ambient temperature 2: H2, conc. HCl / PtO2 / methanol / 2585.7 Torr View Scheme
参考文献
Hacksell, Uli; Arvidsson, Lars-Erik; Svensson, Uno; Nilsson, J. Lars G.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1475 - 1482
反应条件
sodium amalgam; sodium salt of phosphorous acid in methanol T=20°C; 2 h;
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
sodium amalgam; sodium salt of phosphorous acid in methanol T=20°C; 2 h;
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
1: triethylamine / CH2Cl2 2: acetone 3: tetrahydrofuran / 2 h / 20 °C 4: Et3SiH; boron trifluoride etherate / CH2Cl2 / 4 h / 0 °C 5: Na/Hg; sodium phosphate / methanol / 2 h / 20 °C View Scheme
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
1: acetone 2: tetrahydrofuran / 2 h / 20 °C 3: Et3SiH; boron trifluoride etherate / CH2Cl2 / 4 h / 0 °C 4: Na/Hg; sodium phosphate / methanol / 2 h / 20 °C View Scheme
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
1: tetrahydrofuran / 2 h / 20 °C 2: Et3SiH; boron trifluoride etherate / CH2Cl2 / 4 h / 0 °C 3: Na/Hg; sodium phosphate / methanol / 2 h / 20 °C View Scheme
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
反应条件
1: acetone 2: tetrahydrofuran / 2 h / 20 °C 3: Et3SiH; boron trifluoride etherate / CH2Cl2 / 4 h / 0 °C 4: Na/Hg; sodium phosphate / methanol / 2 h / 20 °C View Scheme
参考文献
Chang, Meng-Yang; Hsu, Ru-Ting; Chen, Hua-Ping; Lin, Pei-Jung
Heterocycles, 2006 , vol. 68, # 6 p. 1173 - 1183
