1: 1,4-diaminobutane With trityl chloride resin; triethylamine in dichloromethane
T=20°C; Substitution; 18 h;
2: 6-chloro-9-(β-D-ribofuranosyl)-purine With triethylamine in ethanol; dichloromethane
T=60°C; Substitution; 18 h;
3: With C4H5F5O in dichloromethane
T=20°C; Substitution; 0.25 h; Further stages.;
参考文献
Bressi; Choe; HoughHough; Buckner; Van Voorhis; Verlinde; Hol; Gelb
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4135 - 4150