1-(2-氯乙基)哌啶盐酸盐合成路线 （共 58 条）
反应条件
hydrogenchloride; thionyl chloride in chloroform 1 h; Heating / reflux;
参考文献
Neurochem (International) Limited
Patent: US2006/223855 A1, 2006 ;
Location in patent: Page/Page column 160-161 ;
反应条件
1: in toluene 3 h; Reflux; 2: With thionyl chloride in toluene 2 h; Reflux;
参考文献
CHINA PHARMACEUTICAL UNIVERSITY; Xiang, Hua; Wang, Tianlin; Xiao, Hong; You, Qidong; Yao, Yao; Li, Xiaobo; Liao, Qingjiang
Patent: US2013/85140 A1, 2013 ;
Location in patent: Paragraph 0052; 0053 ;
反应条件
potassium carbonate in acetone T=56°C; 3 h;
参考文献
Li, Xun; Reuman, Michael; Russell, Ronald K.; Adams, Richard; Ma, Robert; Beish, Sandra; Branum, Shawn; Youells, Scott; Roberts, Jerry; Jain, Nareshkumar; Kanojia, Ramesh; Sui, Zhihua
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 414 - 421
反应条件
in dimethyl sulfoxide T=20 - 45°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 8 p. 2535 - 2542
反应条件
potassium carbonate in acetone Reflux;
参考文献
Kumar, Atul; Tripathi, Vishwa Deepak; Kumar, Promod; Gupta, Lalit Prakash; Akanksha; Trivedi, Ritu; Bid, Hemant; Nayak; Siddiqui, Jawed A.; Chakravarti, Bandana; Saxena, Ruchi; Dwivedi, Anila; Siddiquee; Siddiqui; Konwar, Rituraj; Chattopadhyay, Naibedya
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5409 - 5419
反应条件
sodium thiosulfate in water 1 h; Heating;
参考文献
Ukhin, L.Yu.; Akopova; Bicherov; Kuzmina; Morkovnik; Borodkin
Tetrahedron Letters, 2011 , vol. 52, # 42 p. 5444 - 5447
反应条件
caesium carbonate; potassium iodide in N,N-dimethyl-formamide T=25 - 50°C; 14.5 h;
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
反应条件
potassium carbonate in isopropanol acetate; water
参考文献
Eli Lilly and Company
Patent: US5631369 A1, 1997 ;
反应条件
potassium carbonate in isopropanol acetate; water
参考文献
Eli Lilly and Company
Patent: US5631369 A1, 1997 ;
反应条件
potassium carbonate in water; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US5631369 A1, 1997 ;
