N-苄氧羰基-L-亮氨酸合成路线 （共 125 条）
反应条件
1: 93 percent / SOCl2; Et3N / toluene / 2 h / 5 °C
2: 77 percent / Et3N / tetrahydrofuran / 1.33 h / Heating
View Scheme
参考文献
Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
1: N-[(benzyloxy)carbonyl]-L-leucine; diethyl chlorophosphate With triethylamine in tetrahydrofuran
T=15 - 20°C; 3 h;
2: glicine ethyl ester hydrochloride in tetrahydrofuran
T=20 - 25°C; 1 h;
参考文献
Gaede, Bruce
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 92 - 93
参考文献
Crofts et al.
Journal of the Chemical Society, 1959 , p. 3610,3613
反应条件
1: chlorocarbonic acid isobutyl ester; triethylamine; THF / anschliessend mit <2>Naphthylamin
2: HBr; acetic acid
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参考文献
Tuppy; Nesvadba
Monatshefte fuer Chemie, 1957 , vol. 88, p. 977,983
反应条件
1: ethyl acetate; dicyclohexylcarbodiimide
2: triethylamine; CHCl3
3: HBr; acetic acid / Behandeln des Reaktionsprodukts in CHCl3 mit 1-Benzyloxycarbonyl-L-prolin und Triaethylamin
View Scheme
参考文献
Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
tetrahydrofuran; chloroformic acid ethyl ester; triethylamine
anschliessend Behandeln mit L-Valin und wss. NaOH;
参考文献
Baudet; Borecka; Cherbuliez
Helvetica chimica acta, 1968 , vol. 51, # 1 p. 1 - 16
反应条件
tetrahydrofuran; dicyclohexyl-carbodiimide
Behandeln einer Loesung des Reaktionsprodukts in Dioxan und wenig Aceton;
参考文献
Okawa
Bulletin of the Chemical Society of Japan, 1958 , vol. 31, p. 88
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triphenylphosphine; 2aλ3-ioda-2,3-dioxa-cyclopenta[cd]indene-1,4-dione / chloroform / 6 h / 60 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Tian, Jun; Gao, Wen-Chao; Zhou, Dong-Mei; Zhang, Chi
Organic Letters, 2012 , vol. 14, # 12 p. 3020 - 3023
反应条件
1: 1.) Triethylamine, ethyl carbonochloridate / 1.) CHCl3, - 5 deg C, 20 min, 2.) reflux, 30 min
2: KF*2H2O, 18-crown-6 / methanol / 0.08 h / Heating
3: HBr / acetic acid / Ambient temperature; overnight
View Scheme
参考文献
Lejczak, Barbara; Kafarski, Pawel; Szewczyk, Jerzy
Synthesis, 1982 , # 5 p. 412 - 414
反应条件
1: triethylamine, ethyl chloroformate / CHCl3 / 1.) -5 degC, 30 min., 2.) heating to bp.
2: 40percent HBr / acetic acid
View Scheme
参考文献
Lejczak, Barbara; Kafarski, Pawel; Szewczyk, Jerzy
Synthesis, 1982 , # 5 p. 412 - 414
