1,4,5-三甲基-1H-咪唑合成路线 （共 7 条）
反应条件
1: formaldehyd; N-methylamine hydrochloride With ammonium hydroxide 2: 2,3-butadione T=100°C;
参考文献
Zhou, Yirong; Gong, Yuefa
European Journal of Organic Chemistry, 2011 , # 30 p. 6092 - 6099
反应条件
anhydrous ammonium carbonate; formaldehyd in methanol
参考文献
E. I. du Pont de Nemours and Company
Patent: US6177575 B1, 2001 ;
反应条件
potassium hydroxide in dimethyl sulfoxide T=20 - 65°C; 19 h;
参考文献
Heckenroth, Marion; Neels, Antonia; Garnier, Michael G.; Aebi, Philipp; Ehlers, Andreas W.; Albrecht, Martin
Chemistry - A European Journal, 2009 , vol. 15, # 37 p. 9375 - 9386
参考文献
Jowett
Journal of the Chemical Society, 1905 , vol. 87, p. 407
反应条件
1: 1.) nBuLi / 1.) THF, hexane, -40 deg C, 1 h, 2.) THF, hexane, RT, 24 h 2: 78 percent / NaBH4 / methanol / 18 h / Ambient temperature View Scheme
参考文献
Alcalde, Ermitas; Alemany, Montserrat; Gisbert, Maria
Tetrahedron, 1996 , vol. 52, # 48 p. 15171 - 15188
反应条件
1: 1,4,5-trimethyl-1H-imidazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
Zhou, Yirong; Gong, Yuefa
European Journal of Organic Chemistry, 2011 , # 30 p. 6092 - 6099
反应条件
1: 1.) nBuLi / 1.) THF, hexane, -40 deg C, 1 h, 2.) THF, hexane, RT, 24 h
2: 78 percent / NaBH4 / methanol / 18 h / Ambient temperature
3: 67 percent / thionyl chloride / CH2Cl2 / 5 h / Ambient temperature
4: 21 percent / dimethylformamide / 1 h / Ambient temperature
View Scheme
参考文献
Alcalde, Ermitas; Alemany, Montserrat; Gisbert, Maria
Tetrahedron, 1996 , vol. 52, # 48 p. 15171 - 15188
