1.1: potassium carbonate / acetonitrile / 4 h / 40 °C 2.1: potassium carbonate; water / methanol / 1 h / 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 110 °C 4.1: N-bromosuccinmide / N,N-dimethyl-formamide / 16 h / 20 °C 5.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethylene glycol dimethyl ether; water / 12 h / 60 °C / |Inert atmosphere 6.1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 20 °C 6.2: 16 h / 20 °C 7.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene / dichloromethane / 48 h / 20 °C 8.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 5 h / 0 - 45 °C 8.2: 0 - 20 °C 9.1: palladium 10 on activated carbon; hydrogen / methanol / 6 h / 22502.3 Torr View Scheme

Candida cylindracea lipase in di-isopropyl ether; butan-1-ol T=28 - 30°C; 10 h;

暂无反应条件数据

1: 99 percent / K2CO3 / dimethylformamide / 3 h / 40 °C 2: 99 percent / K2CO3 / methanol; H2O / 0.33 h / Ambient temperature View Scheme

1: With potassium carbonate in N,N-dimethyl-formamide 2: With water; potassium carbonate in methanol Further stages.;

potassium carbonate in N,N-dimethyl-formamide T=40°C; 3 h;

1: potassium carbonate / acetonitrile / 4 h / 40 °C 2: potassium carbonate; water / methanol / 1 h / 20 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 110 °C View Scheme

thionyl chloride in chloroform; N,N-dimethyl-formamide Reflux;

1.1: thionyl chloride / chloroform; N,N-dimethyl-formamide / |Reflux 2.1: pyridine / 20 °C 3.1: potassium hydroxide / pyridine / 0.33 h / 50 °C 3.2: 0.5 h 3.3: |Reflux View Scheme