2-(噻吩甲基)膦酸二乙酯合成路线 （共 24 条）
参考文献
Jen, Alex K-Y.; Rao, V. Pushkara; Wong, K. Y.; Drost, Kevin J.
Journal of the Chemical Society, Chemical Communications, 1993 , # 1 p. 90 - 92
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Rao, V. Pushkara; Jen, Alex K-Y.; Wong, K. Y.; Drost, Kevin J.
Tetrahedron Letters, 1993 , vol. 34, # 11 p. 1747 - 1750
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.75 h; 2: With copper(l) iodide in tetrahydrofuran; hexane T=-20°C; transmetallation; 2 h; 3: iodomethylphosphonic acid diethyl ester in tetrahydrofuran; hexane T=20°C; Alkylation;
参考文献
Wang, Chuanguang; Dalton, Larry R.
Tetrahedron Letters, 2000 , vol. 41, # 5 p. 617 - 620
反应条件
T=125°C; Arbuzov reaction; 4 h; Inert atmosphere;
参考文献
Younes, Ali H.; Zhang, Lu; Clark, Ronald J.; Davidson, Michael W.; Zhu, Lei
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 23 p. 5431 - 5441
反应条件
copper(l) iodide; caesium carbonate in ethylene glycol dimethyl ether T=80°C; 2 h; Inert atmosphere;
参考文献
Miao, Wenjun; Gao, Yuzhen; Li, Xueqin; Gao, Yuxing; Tang, Guo; Zhao, Yufen
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 14-15 p. 2659 - 2664
反应条件
1: 91 percent / thionyl chloride / CH2Cl2 / 20 - 32 °C 2: 97 percent / 7 h / 160 °C View Scheme
参考文献
Synthetic Communications, , vol. 35, # 15 p. 2079 - 2083
参考文献
Synthesis, , # 9 p. 1131 - 1134
反应条件
iodine T=0 - 125°C; 12 h;
参考文献
Zheng, Shijun; Barlow, Stephen; Parker, Timothy C.; Marder, Seth R.
Tetrahedron Letters, 2003 , vol. 44, # 43 p. 7989 - 7992
反应条件
1: thiophene; formaldehyd With hydrogen bromide; acetic acid T=5 - 20°C; 2: triethyl phosphite Arbuzov reaction; 1 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 70, # 15 p. 6004 - 6017
反应条件
1: N-bromosuccinmide / tetrachloromethane 2: 140 °C View Scheme
参考文献
Molecular Crystals and Liquid Crystals, , vol. 520, p. 186 - 192
Molecular Crystals and Liquid Crystals, , vol. 539, p. 442 - 448
