反应条件
1.1: 100 percent / KF; tris(dibenzylideneacetone)dipalladium; tri-tert-butylphosphine / tetrahydrofuran; dioxane / 0.75 h / 20 - 50 °C
2.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 2 h / -78 °C
2.2: 67 percent / trimethyl borate / hexane; tetrahydrofuran / -78 - 20 °C
View Scheme
参考文献
Goodacre, Simon C.; Street, Leslie J.; Hallett, David J.; Crawforth, James M.; Kelly, Sarah; Owens, Andrew P.; Blackaby, Wesley P.; Lewis, Richard T.; Stanley, Joanna; Smith, Alison J.; Ferris, Pushpinder; Sohal, Bindi; Cook, Susan M.; Pike, Andrew; Brown, Nicola; Wafford, Keith A.; Marshall, George; Castro, Jose L.; Atack, John R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 1 p. 35 - 38
