反应条件
1: 1.) N,N,N',N'-tetramethylethylene diamine, n-BuLi; n-Bu3SnCl, 2.) PdCl2(PPh3)2 / 1.) Et2O, reflux, 1 h; Et2O, -70 deg C, 4 h, 2.) THF, reflux, 70 h 2: 58 percent / POCl3 / 18 h / 90 °C 3: 96 percent / NaBH4 / methanol; CH2Cl2 / 18 h / Ambient temperature 4: 98 percent / SOCl2, Et3N / CH2Cl2 / 1.) r.t., 1 h, 2.) 40 deg C, 0.5 h 5: 85 percent / K2CO3, KOH / BBDECl / acetonitrile / 40 h / Ambient temperature View Scheme
参考文献
Delgado; Pastor; Garcia-Navio; Vaquero; Alvarez-Builla; Sunkel; De Casa-Juana; Priego; Santos; Statkow; Straumann
Farmaco, 1997 , vol. 52, # 3 p. 147 - 155
