1-甲基-1H-咪唑-2-羧酸合成路线 （共 11 条）
反应条件
1: ethyl 1-methyl-imidazole-2-carboxylate With sodium hydroxide; water 1 h; Heating / reflux; 2: C5H5N2O2(1-)*Na(1+) With hydrogenchloride in water T=5 - 50°C; pH=2;
参考文献
MERCK and CO., INC.
Patent: WO2004/58763 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/058763 A1
反应条件
1: With sodium hydroxide in water 1 h; Reflux; 2: With hydrogenchloride in water pH=2;
参考文献
Jimenez-Balsa, Adrian; Dodero, Veronica I.; Mascarenas, Jose L.
Tetrahedron, 2013 , vol. 69, # 36 p. 7847 - 7853
反应条件
triethylamine in acetonitrile
参考文献
Genesoft, Inc.
Patent: US6143901 A1, 2000 ;
反应条件
1: carbon dioxide With [Au(1,3-bis(tert-butyl)imidazol-2-ylidene)(OH)]; potassium hydroxide in tetrahydrofuran T=20°C; P=1125.11 Torr; 0.25 h; 2: 1-methyl-1H-imidazole in tetrahydrofuran T=20°C; P=1125.11 Torr; 12 h; 3: With hydrogenchloride in tetrahydrofuran; water regioselective reaction;
参考文献
Boogaerts, Ine I. F.; Nolan, Steven P.
Journal of the American Chemical Society, 2010 , vol. 132, # 26 p. 8858 - 8859
反应条件
dihydrogen peroxide in water T=20°C; 72 h;
参考文献
Walmsley, Ryan S.; Tshentu, Zenixole R.
South African Journal of Chemistry, 2010 , vol. 63, p. 95 - 104
反应条件
anschliessend mit CO2;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 4922,4926
反应条件
anschliessend mit CO2;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 4922,4926
反应条件
anschl. mit festem CO2;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 4922,4926
反应条件
tert.-butyl lithium 1.) THF, -70 deg C, 2.) decarboxylation; Yield given. Multistep reaction;
参考文献
Shapiro; Gomez-Lor
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5524 - 5526
反应条件
tert.-butyl lithium
1.) THF, -70 deg C, 2.) decarboxylation; Yield given. Multistep reaction;
参考文献
Shapiro; Gomez-Lor
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5524 - 5526
