1-甲基-1H-苯并咪唑-2-羧酸合成路线 （共 17 条）
反应条件
1.1: acetic acid / 1 h / 20 °C 2.1: sodium carbonate / 14 h / Reflux 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 4 h / 20 °C 4.1: sodium hydroxide; water / methanol / 1 h / 50 °C 4.2: pH 2 View Scheme
参考文献
WO2011/143365 A1, ;
WO 2011/143365 A1
反应条件
1.1: sodium carbonate / 14 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 2.2: 4 h / 20 °C 3.1: sodium hydroxide; water / methanol / 1 h / 50 °C 3.2: pH 2 View Scheme
参考文献
WO2011/143365 A1, ;
WO 2011/143365 A1
反应条件
1: diethyl ether; sodium amide; liquid NH3 2: butyl lithium; diethyl ether / -60 °C / Behandeln des Reaktionsgemisches mit festem CO2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1791
反应条件
acetic acid unter starker Kuehlung;
参考文献
Journal of the Chemical Society, , vol. 123, p. 1082
反应条件
T=-60°C; Behandeln des Reaktionsgemisches mit festem CO2;
参考文献
Journal of Organic Chemistry, , vol. 23, p. 1791
参考文献
Usherwood; Whiteley
Journal of the Chemical Society, 1923 , vol. 123, p. 1082
反应条件
oxalyl dichloride in DMF (N,N-dimethyl-formamide); dichloromethane
T=0 - 20°C; 4.25 h;
参考文献
Betschmann, Patrick; Burchat, Andrew; Calderwood, David; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin; Hrnciar, Peter; Michaelides, Michael; Rafferty, Paul
Patent: US2005/20619 A1, 2005 ;
Location in patent: Page 69 ;
US 20050020619 A1
